Evidence map›Paper›PMID 31609520›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2019

Hepatitis C-positive donor liver transplantation for hepatitis C seronegative recipients.

Peng-Sheng Ting, James Peter Hamilton, Ahmet Gurakar, Nathalie H Urrunaga, Michelle Ma, Jaime Glorioso, Elizabeth King, Lindsey P Toman, Russell Wesson, Jacqueline Garonzik-Wang and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Trends in candidate hepatitis C virus nucleic acid amplification test (NAT)+ listing and associated impacts on liver transplantation waitlist outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Present and future management of viral hepatitis.World journal of gastroenterology · 2021
    Review
  11. Article
  12. Article
  13. Post-transplant survey to assess patient experiences with donor-derived HCV infection.Transplant infectious disease : an official journal of the Transplantation Society · 2020
    Article
  14. Article
  15. Donor Evaluation Protocol for Live and Deceased Donors.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Peng-Sheng TingDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-1581-2354
James Peter HamiltonDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-3137-7567
Ahmet GurakarDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-2221-9148
Nathalie H UrrunagaDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michelle MaDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jaime GloriosoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elizabeth KingDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lindsey P TomanDepartment of Pharmacy, Johns Hopkins Hospital, Baltimore, MD, USA.
Russell WessonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jacqueline Garonzik-WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-2789-7503
Shane OttmannDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Benjamin PhilosopheDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mark SulkowskiDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-2145-6352
Andrew M CameronDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christine M DurandDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-2605-9257
Po-Hung ChenDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-9865-1009
Johns Hopkins University · USJohns Hopkins Hospital · US

Funding

Institute for Clinical and Translational ResearchKL2TR001077 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$9.2M
Patient Oriented Research in Hepatitis C-infected Injection Drug UsersK24DA034621 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SULKOWSKI, MARK SEBASTIAN · 2012 to 2022
$1.2M
Optimal Antiretroviral Therapy During Bone Marrow Transplant in HIV-1 InfectionK23CA177321 · NCI · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE · 2014 to 2018
$808k
Aggressive Center Report Cards to Safely Increase Transplantation of Suboptimal KidneysK23DK115908 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI GARONZIK WANG, JACQUELINE M · 2018 to 2021
$516k
Johns Hopkins Institute for Clinical and Translational Research (ICTR) and the National Center for Advancing Translational Sciences (NCATS) KL2TR001077National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K23DK115908NCATS NIH HHS KL2 TR001077NCI NIH HHS K23 CA177321NCI NIH HHS K23CA177321NIDA NIH HHS K24 DA034621NIDA NIH HHS K24DA034621NIDDK NIH HHS K23 DK115908
6 · The paper itself

Abstract

backgroundThe opioid crisis has led to an increase in hepatitis C virus-positive donors in the past decade. Whereas historically hepatitis C seropositive organs were routinely discarded, the advent of direct-acting antiviral agents has notably expanded the utilization of organs from donors with hepatitis C. There has been growing experience with liver transplantation (LT) from hepatitis C seropositive donors to hepatitis C seropositive recipients. However, data remain limited on LT from hepatitis C seropositive or hepatitis C ribonucleic acid positive donors to hepatitis C seronegative recipients.

methodsWe performed a retrospective study of 26 hepatitis C seronegative recipients who received hepatitis C seropositive donor livers followed by preemptive antiviral therapy with direct-acting antiviral treatment at the Johns Hopkins Hospital Comprehensive Transplant Center from January 1, 2017, to August 31, 2019.

resultsTwenty-five of the 26 recipients are alive with proper graft function; 20 of them received livers from hepatitis C nucleic acid testing positive donors. All 12 recipients who completed their direct-acting antiviral courses and have reached sufficient follow-up for sustained virologic response have achieved sustained virologic response. Nine of our recipients have either completed direct-acting antiviral treatment without sufficient follow-up time for sustained virologic response or are undergoing direct-acting antiviral treatment. One patient is awaiting antiviral treatment initiation pending insurance approval. Of note, 11 of 12 patients with sustained virologic response received a hepatitis C nucleic acid testing positive donor liver.

conclusionHepatitis C seronegative patients who receive a hepatitis C seropositive or hepatitis C nucleic acid testing positive liver allograft can enjoy good short-term outcomes with hepatitis C cure following direct-acting antiviral treatment.

Indexed as

AdultAgedAllograftsAntibiotic ProphylaxisAntiviral AgentsDonor SelectionFemaleHepacivirusHepatitis CHumansLiverLiver TransplantationMaleMiddle AgedRetrospective StudiesRNA, ViralAntiviral AgentsRNA, Viraldirect-acting antiviralhepatitis C virus-negative recipienthepatitis C virus-positive donor liverliver transplantationpreemptive antiviral therapy

Identifiers

PMID31609520
PMCPMC7259815
OpenAlexW2980472629

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.