SynthesisPsychological medicine2020
An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium.
Synthesis in Psychological medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Suicidal risk in patients with aggression in schizophrenia: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Associations among homocysteine, left cortical thickness, and working memory in patients with treatment-resistant schizophrenia: preliminary findings of a cohort study.BMC psychiatry · 2026Article
- Prevalence and clinical correlates of suicidal ideation and aggression in patients with chronic schizophrenia: large-scale, cross-sectional study.BJPsych open · 2026Article
- Widespread cortical thinning and subcortical alterations in mood and psychotic disorders across first-episode and chronic stages.Journal of affective disorders · 2026Article
- Abnormal eye movement, brain regional homogeneity in schizophrenia and clinical high-risk individuals and their associated gene expression profiles.Schizophrenia (Heidelberg, Germany) · 2025Article
- Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset.Molecular psychiatry · 2024Article
- Factor analysis of lifetime psychopathology and its brain morphometric and genetic correlates in a transdiagnostic sample.Translational psychiatry · 2024Article
- Psychosis superspectrum II: neurobiology, treatment, and implications.Molecular psychiatry · 2024Review
- Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium.medRxiv : the preprint server for health sciences · 2024Article
- Putting the usability of wearable technology in forensic psychiatry to the test: a randomized crossover trial.Frontiers in psychiatry · 2024Article
- Modelling the overlap and divergence of autistic and schizotypal traits on hippocampal subfield volumes and regional cerebral blood flow.Molecular psychiatry · 2024Article
- Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study.Research square · 2023Article
- Cumulative Impact of Morphometric Features in Schizophrenia in Two Independent Samples.Schizophrenia bulletin open · 2023Article
- Potential diagnostic biomarkers for schizophrenia.Medical review (2021) · 2022Review
- Resistance to Extinction of Evaluative Fear Conditioning in Delusion Proneness.Schizophrenia bulletin open · 2022Article
- Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA.Human brain mapping · 2022Review
- Abnormal Brain Structure Morphology in Early-Onset Schizophrenia.Frontiers in psychiatry · 2022Article
- Prenatal maternal stress and offspring aggressive behavior: Intergenerational and transgenerational inheritance.Frontiers in behavioral neuroscience · 2022Review
- Allostatic Load Effects on Cortical and Cognitive Deficits in Essentially Normotensive, Normoweight Patients with Schizophrenia.Schizophrenia bulletin · 2021Article
- Effects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia.Translational psychiatry · 2021Article
Corrections and comments
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Authors and funding
66 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPositive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.
methodTo study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.
resultsThe result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.
conclusionThese findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.