Evidence map›Paper›PMID 31620102›Full record

ReviewFrontiers in microbiology2019

Biomarkers and Preclinical Models for Adult T-Cell Leukemia-Lymphoma Treatment.

Lee Ratner

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Lee RatnerDivision of Oncology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States.

Funding

Role of Inflammation in Tax-mediated TumorigenesisP01CA100730 · NCI · WASHINGTON UNIVERSITY · PI Lee Ratner · 2003 to 2026
$44.8M
PROLIFERATIVE EFFECTS OF HTLV1R01CA063417 · NCI · WASHINGTON UNIVERSITY · PI RATNER, LEE · 1995 to 2017
$3.7M
IMMUNE CHECKPOINT BLOCKADE PROMOTES ADULT T CELL LEUKEMIAR21CA234640 · NCI · WASHINGTON UNIVERSITY · PI RATNER, LEE · 2019 to 2020
$375k
NCI NIH HHS P01 CA100730NCI NIH HHS R01 CA063417NCI NIH HHS R21 CA234640
6 · The paper itself

Abstract

Adult T-cell leukemia/lymphoma (ATL) is an aggressive lymphoproliferative malignancy with a very poor prognosis. Despite several recent advances, new therapeutic approaches are critical, and this will require successful preclinical studies, including studies in ATL cell culture systems, and mouse models. Identification of accurate, reproducible biomarkers will be a crucial component of preclinical and clinical studies. This review summarizes the current state-of-the-art in each of these fields, and provides recommendations for future approaches. This problem is an important unmet need in HTLV research.

Indexed as

adult T-cell leukemia-lymphomabiomarkersHBZmouse modelspreclinicaltaxxenograft

Identifiers

PMID31620102
PMCPMC6759749

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.