Evidence map›Paper›PMID 31622047›Full record

ArticleJournal of diabetes investigation2020

Transplantation of adipose-derived mesenchymal stem cell sheets directly into the kidney suppresses the progression of renal injury in a diabetic nephropathy rat model.

Shunsuke Takemura, Tatsuya Shimizu, Masatoshi Oka, Sachiko Sekiya, Tetsuya Babazono

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Kidney-Derived ECM Hydrogels as Cell Delivery Devices.ACS applied materials & interfaces · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Molecular Therapeutics for Diabetic Kidney Disease: An Update.International journal of molecular sciences · 2024
    Review
  10. Review
  11. The therapeutic effect of mesenchymal stem cells in diabetic kidney disease.Journal of molecular medicine (Berlin, Germany) · 2024
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. hucMSC-sEVs-Derived 14-3-3Oxidative medicine and cellular longevity · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shunsuke TakemuraDepartment of Medicine, Diabetes Center, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.ORCID https://orcid.org/0000-0002-6157-6834
Tatsuya ShimizuInstitute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan.
Masatoshi OkaDepartment of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
Sachiko SekiyaInstitute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan.
Tetsuya BabazonoDepartment of Medicine, Diabetes Center, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8545-3604
Tokyo Women's Medical University · JP

Funding

CellSeed Inc.
6 · The paper itself

Abstract

AIMS/

introductionAdipose-derived mesenchymal stem cell (ASC) transplantation is a promising therapy for diabetic nephropathy (DN). However, intravascular administration of ASCs is associated with low engraftment in target organs. Therefore, we considered applying the cell sheet technology to ASCs. In this study, ASC sheets were directly transplanted into the kidneys of a DN rat model, and therapeutic consequences were analyzed. MATERIALS AND

methodsAdipose-derived mesenchymal stem cells were isolated from adipose tissues of 7-week-old enhanced green fluorescent protein rats, and ASC sheets were prepared using a temperature-responsive culture dish. A DN rat model was established from 5-week-old Spontaneously Diabetic Torii fatty rats. Seven-week-old DN rats (n = 21) were assigned to one of the following groups: sham-operated (n = 6); ASC suspension (6.0 × 10

resultsThe ASC sheets survived under the kidney capsule of the DN rat model for 14 days after transplantation. Furthermore, albuminuria and urinary tumor necrosis factor-α levels were significantly lower in the ASC sheets transplanted directly into the kidney group than in the sham-operated and ASC suspension administered intravenously groups (P < 0.05). Histologically, the ASC sheets transplanted directly into the kidney group presented mild atrophy of the proximal tubule and maintained the renal tubular structure.

conclusionsTransplantation of ASC sheets directly into the kidney improved transplantation efficiency and suppressed renal injury progression. Therefore, the ASC sheet technology might be a promising novel treatment for DN.

Indexed as

Mesenchymal Stem Cell TransplantationAcute Kidney InjuryAnimalsCells, CulturedDiabetic NephropathiesDisease Models, AnimalKidneyMaleMesenchymal Stem CellsRatsAdipose-derived mesenchymal stem cellCell sheetRenal injury

Identifiers

PMID31622047
PMCPMC7232293
OpenAlexW2981292754

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.