Evidence map›Paper›PMID 31644668›Full record

SynthesisArquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery2019

ASSOCIATION OF RS2435357 AND RS1800858 POLYMORPHISMS IN RET PROTO-ONCOGENE WITH HIRSCHSPRUNG DISEASE: SYSTEMATIC REVIEW AND META-ANALYSIS.

Abdolhamid Amooee, Mohamad Hosein Lookzadeh, Seyed Reza Mirjalili, Seyed Mohsen Miresmaeili, Kazem Aghili, Masoud Zare-Shehneh, Hossein Neamatzadeh

Open access · diamondAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Is There Any Mosaicism inFrontiers in pediatrics · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Abdolhamid AmooeeShahid Sadoughi University of Medical Sciences, General Surgery.ORCID http://orcid.org/0000-0002-0864-341X
Mohamad Hosein LookzadehShahid Sadoughi University of Medical Sciences, Pediatrics.
Seyed Reza MirjaliliShahid Sadoughi University of Medical Sciences, Pediatrics.
Seyed Mohsen MiresmaeiliScience and Art University, Biology.
Kazem AghiliShahid Sadoughi University of Medical Sciences, Radiology.
Masoud Zare-ShehnehShahid Sadoughi University of Medical Sciences, Medical Genetics, Yazd, Yazd, Iran.
Hossein NeamatzadehShahid Sadoughi University of Medical Sciences, Medical Genetics, Yazd, Yazd, Iran.
Shahid Sadoughi University of Medical Sciences and Health Services · IRTehran University of Art · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMany published studies have estimated the association of rs2435357 and rs1800858 polymorphisms in the proto-oncogene rearranged during transfection (RET) gene with Hirschsprung disease (HSCR) risk. However, the results remain inconsistent and controversial.

aimTo perform a meta-analysis get a more accurate estimation of the association of rs2435357 and rs1800858 polymorphisms in the RET proto-oncogene with HSCR risk.

methodsThe eligible literatures were searched by PubMed, Google Scholar, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) up to June 30, 2018. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to HSCR.

resultsA total of 20 studies, including ten (1,136 cases 2,420 controls) for rs2435357 and ten (917 cases 1,159 controls) for rs1800858 were included. The overall results indicated that the rs2435357 (allele model: OR=0.230, 95% CI 0.178-0.298, p=0.001; homozygote model: OR=0.079, 95% CI 0.048-0.130, p=0.001; heterozygote model: OR=0.149, 95% CI 0.048-0.130, p=0.001; dominant model: OR=0.132, 95% CI 0.098-0.179, p=0.001; and recessive model: OR=0.239, 95% CI 0.161-0.353, p=0.001) and rs1800858 (allele model: OR=5.594, 95% CI 3.653-8.877, p=0.001; homozygote model: OR=8.453, 95% CI 3.783-18.890, p=0.001; dominant model: OR=3.469, 95% CI 1.881-6.396, p=0.001; and recessive model: OR=6.120, 95% CI 3.608-10.381, p=0.001) polymorphisms were associated with the increased risk of HSCR in overall.

conclusionsThe results suggest that the rs2435357 and rs1800858 polymorphisms in the RET proto-oncogene might be associated with HSCR risk.

Indexed as

Genetic Predisposition to DiseaseHirschsprung DiseaseHumansPolymorphism, GeneticProto-Oncogene MasProto-Oncogene Proteins c-retSensitivity and SpecificityMAS1 protein, humanProto-Oncogene MasProto-Oncogene Proteins c-ret

Identifiers

PMID31644668
PMCPMC6812143
OpenAlexW2980772652

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.