ArticleMemorias do Instituto Oswaldo Cruz2019
A case of sporotrichosis caused by different Sporothrix brasiliensis strains: mycological, molecular, and virulence analyses.
Article in Memorias do Instituto Oswaldo Cruz, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Human and Feline Sporotrichosis in a Reference Center of Southeastern Brazil: Genetic Differentiation, Diversity, and Antifungal Susceptibility ofJournal of fungi (Basel, Switzerland) · 2023Article
- Article
- Sporotrichosis in Children: Case series and Narrative Review.Current fungal infection reports · 2022Review
- Clinical and Anatomopathological Evaluation of BALB/c Murine Models Infected with Isolates of Seven PathogenicPathogens (Basel, Switzerland) · 2021Article
- Sporothrix globosa melanin inhibits antigenpresentation by macrophages and enhances deep organ dissemination.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Review
- Article
- Influences of the Culturing Media in the Virulence and Cell Wall ofJournal of fungi (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSporotrichosis is a subcutaneous mycosis caused by dimorphic pathogenic fungi belonging to the Sporothrix genus. Pathogenic Sporothrix species typically produce melanin, which is known to be a virulence factor.
objectivesThe aim of this study was to perform phenotypic, genotypic, and virulence analyses of two distinct Sporothrix brasiliensis strains isolated from the same lesion on a patient from Rio de Janeiro. METHODS AND
findingsGenotypic analyses by partial sequencing of the calmodulin, β-tubulin, and chitin synthase genes, as well as polymerase chain reaction (PCR)-fingerprinting by T3B, M13, and GACA, showed that the isolates were very similar but not identical. Both isolates had similar phenotypic characteristics and effectively produced melanin in their yeast forms, accounting for their ability of causing disease in a murine sporotrichosis model. Remarkably, isolate B was albino in its environmental form but caused more severe disease than the pigmented A isolate.
conclusionsThese findings indicate that the patient was infected by two genetically and biologically distinct S. brasiliensis that vary in their production of melanin in their environmental forms. The results underscore the importance of characterizing phenotypically different isolates found in the same clinical specimen or patient.
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