Evidence map›Paper›PMID 31645462›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

The Origin of GnRH Pulse Generation: An Integrative Mathematical-Experimental Approach.

Margaritis Voliotis, Xiao Feng Li, Ross De Burgh, Geffen Lass, Stafford L Lightman, Kevin T O'Byrne, Krasimira Tsaneva-Atanasova

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. New methods to investigate the GnRH pulse generator.Journal of molecular endocrinology · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Analysis ofGenes · 2023
    Article
  12. Hypothalamic Kisspeptin Neurons: Integral Elements of the GnRH System.Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Review
  13. Article
  14. Modelling KNDy neurons and gonadotropin-releasing hormone pulse generation.Current opinion in endocrine and metabolic research · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Mathematical models in GnRH research.Journal of neuroendocrinology · 2022
    Review
  19. Optogenetic stimulation of Kiss1Frontiers in endocrinology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Margaritis VoliotisDepartment of Mathematics and Living Systems Institute, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QF, United Kingdom, M.Voliotis@exeter.ac.uk K.Tsaneva-Atanasova@exeter.ac.uk.ORCID 0000-0001-6488-7198
Xiao Feng LiDepartment of Women and Children's Health, School of Life Course Sciences, King's College London, London SE1 1UL, United Kingdom, and.
Ross De BurghDepartment of Women and Children's Health, School of Life Course Sciences, King's College London, London SE1 1UL, United Kingdom, and.
Geffen LassDepartment of Women and Children's Health, School of Life Course Sciences, King's College London, London SE1 1UL, United Kingdom, and.
Stafford L LightmanHenry Wellcome Laboratory for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, United Kingdom.
Kevin T O'ByrneDepartment of Women and Children's Health, School of Life Course Sciences, King's College London, London SE1 1UL, United Kingdom, and.
Krasimira Tsaneva-AtanasovaDepartment of Mathematics and Living Systems Institute, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QF, United Kingdom, M.Voliotis@exeter.ac.uk K.Tsaneva-Atanasova@exeter.ac.uk.
King's College London · GBEngineering and Physical Sciences Research Council · GBUniversity of Bristol · GB

Funding

Biotechnology and Biological Sciences Research Council BB/S001255/1Medical Research Council MR/N022637/1
6 · The paper itself

Abstract

Fertility critically depends on the gonadotropin-releasing hormone (GnRH) pulse generator, a neural construct comprised of hypothalamic neurons coexpressing kisspeptin, neurokoinin-B and dynorphin. Here, using mathematical modeling and

Indexed as

AnimalsDynorphinsEstrous CycleFeedback, PhysiologicalFemaleGonadotropin-Releasing HormoneKisspeptinsLuteinizing HormoneMiceMice, Inbred C57BLMice, TransgenicModels, TheoreticalNeurokinin BNeuronsOptogeneticsPregnancyDynorphinsGonadotropin-Releasing HormoneKisspeptinsLuteinizing HormoneNeurokinin Barcuate nucleusfertilitygonadotrophin-releasing hormonekisspeptin neuronsmathematical model

Identifiers

PMID31645462
PMCPMC6891054
OpenAlexW2981370465

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.