Evidence map›Paper›PMID 31646474›Full record

ArticleObesity surgery2020

The Long-term Impact of Roux-en-Y Gastric Bypass on Colorectal Polyp Formation and Relation to Weight Loss Outcomes.

Hisham Hussan, Alyssa Drosdak, Melissa Le Roux, Kishan Patel, Kyle Porter, Steven K Clinton, Brian Focht, Sabrena Noria

Abstract read
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In one paragraph

Article in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hisham HussanDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH, USA. hisham.hussan@osumc.edu.ORCID 0000-0002-8646-8370
Alyssa DrosdakDepartment of Internal Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Melissa Le RouxOhio State University College of Medicine, Columbus, OH, USA.
Kishan PatelDepartment of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH, USA.
Kyle PorterCenter for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Steven K ClintonThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Brian FochtDepartment of Human Sciences, Ohio State University, Columbus, OH, USA.
Sabrena NoriaDivision of General and Gastrointestinal Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
The Ohio State University Wexner Medical Center · USThe Ohio State University · USUniversity Hospitals of Cleveland · US

Funding

NIH HHS UL1TR002733
6 · The paper itself

Abstract

backgroundEvolving epidemiological data, backed by mechanistic evidence, supports a paradoxical increase in the risk of colorectal cancer after Roux-en-Y gastric bypass surgery (RYGB). We examined the risk of colonic polyps after RYGB.

methodsA single-center retrospective study included colonoscopies performed between the years 1994 and 2018. To focus on the long-term impact of RYGB on precancerous colonic polyps, we compared patients at average risk for CRC who underwent colonoscopy ≥ 5 years after RYGB (n = 86) versus pre-RYGB (n = 106). We analyzed our data using inverse probability of treatment weighting (IPTW) using propensity scores in order to account for multiple potential confounders.

resultsAfter IPTW, we found no statistical differences between pre- and post-RYGB patients for risk of any polyp (33.2% pre- vs. 32.7% post-RYGB). However, the percentage of serrated polyps was higher ≥ 5 years post-RYGB compared with pre-RYGB (8.7% vs. 2.1%, p = 0.04, relative risk = 4.22; 95% CI 0.97, 18.4). Body mass index ≥ 30 kg/m

conclusionOur data suggest that RYGB is associated with an increased risk of serrated polyps after 5 years from surgery. Prospective studies defining this risk and examining mechanisms will be instrumental for application of CRC preventative strategies in this population.

Indexed as

Gastric BypassAgedBody Mass IndexColonic PolypsColonoscopyColorectal NeoplasmsFemaleFollow-Up StudiesHumansMaleMiddle AgedObesity, MorbidOhioPrecancerous ConditionsRetrospective StudiesRisk FactorsBariatric surgeryColorectalGastric bypassNeoplasiaPolypsRoux-en-Y

Identifiers

PMID31646474
OpenAlexW2981968205

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.