ReviewFrontiers in human neuroscience2019
Brainstem Modulation of Large-Scale Intrinsic Cortical Activity Correlations.
Review in Frontiers in human neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Pupil size is linked to opposite signal fluctuations between cortical BOLD and ventricular CSF.NeuroImage · 2026Article
- Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque.eLife · 2026Article
- Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026Article
- Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics.Nature communications · 2025Article
- Arousal increases locus coeruleus blood flow, salience-related brain responses, and modulates negative-valence attentional biases.bioRxiv : the preprint server for biology · 2025Article
- Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Functional contrast across the gray-white matter boundary.Nature communications · 2025Article
- Cognitive Impairment Caused by Isolated Adrenocorticotropic Hormone Deficiency Mimicking Dementia with Lewy Bodies.Internal medicine (Tokyo, Japan) · 2025Article
- Cortico-subcortical networks that determine behavioral memory renewal are redefined by noradrenergic neuromodulation.Scientific reports · 2025Article
- Multimodal state-dependent connectivity analysis of arousal and autonomic centers in the brainstem and basal forebrain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Behavioural stochastic resonance across the lifespan.Cognitive, affective & behavioral neuroscience · 2024Article
- Integrating brainstem and cortical functional architectures.Nature neuroscience · 2024Article
- Distinct Longitudinal Changes in EEG Measures Reflecting Functional Network Disruption in ALS Cognitive Phenotypes.Brain topography · 2024Article
- Heritability of functional gradients in the human subcortico-cortical connectivity.Communications biology · 2024Article
- Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression.PLoS computational biology · 2024Article
- Acetylcholine Engages Distinct Amygdala Microcircuits to Gate Internal Theta Rhythm.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Functionality of arousal-regulating brain circuitry at rest predicts human cognitive abilities.bioRxiv : the preprint server for biology · 2024Article
- Intrinsic timescales and predictive allostatic interoception in brain health and disease.Neuroscience and biobehavioral reviews · 2024Review
- Representational maps in the brain: concepts, approaches, and applications.Frontiers in cellular neuroscience · 2024Review
- Hypoperfusion in Supramarginal and Orbital Gyrus, Position Discrimination Test, and Microsaccades as a Predictor of Pisa Syndrome in Parkinson's Disease.Parkinson's disease · 2024Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Brain activity fluctuates continuously, even in the absence of changes in sensory input or motor output. These intrinsic activity fluctuations are correlated across brain regions and are spatially organized in macroscale networks. Variations in the strength, topography, and topology of correlated activity occur over time, and unfold upon a backbone of long-range anatomical connections. Subcortical neuromodulatory systems send widespread ascending projections to the cortex, and are thus ideally situated to shape the temporal and spatial structure of intrinsic correlations. These systems are also the targets of the pharmacological treatment of major neurological and psychiatric disorders, such as Parkinson's disease, depression, and schizophrenia. Here, we review recent work that has investigated how neuromodulatory systems shape correlations of intrinsic fluctuations of large-scale cortical activity. We discuss studies in the human, monkey, and rodent brain, with a focus on non-invasive recordings of human brain activity. We provide a structured but selective overview of this work and distil a number of emerging principles. Future efforts to chart the effect of specific neuromodulators and, in particular, specific receptors, on intrinsic correlations may help identify shared or antagonistic principles between different neuromodulatory systems. Such principles can inform models of healthy brain function and may provide an important reference for understanding altered cortical dynamics that are evident in neurological and psychiatric disorders, potentially paving the way for mechanistically inspired biomarkers and individualized treatments of these disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.