Evidence map›Paper›PMID 31649539›Full record

ArticleFrontiers in pharmacology2019

Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico.

Vanessa Gonzalez-Covarrubias, Marlet Morales-Franco, Omar F Cruz-Correa, Angélica Martínez-Hernández, Humberto García-Ortíz, Francisco Barajas-Olmos, Alma Delia Genis-Mendoza, José Jaime Martínez-Magaña, Humberto Nicolini, Lorena Orozco and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  5. Frontiers in pharmacology · 2024
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  13. Influence of Genetic Admixture Components onFrontiers in pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Vanessa Gonzalez-CovarrubiasPharmacogenomics Laboratory, INMEGEN, CDMX, Mexico City, Mexico.
Marlet Morales-FrancoPharmacogenomics Laboratory, INMEGEN, CDMX, Mexico City, Mexico.
Omar F Cruz-CorreaPharmacogenomics Laboratory, INMEGEN, CDMX, Mexico City, Mexico.
Angélica Martínez-HernándezImmunogenomics and Metabolic Diseases Laboratory, INMEGEN, CDMX, Mexico City, Mexico.
Humberto García-OrtízImmunogenomics and Metabolic Diseases Laboratory, INMEGEN, CDMX, Mexico City, Mexico.
Francisco Barajas-OlmosImmunogenomics and Metabolic Diseases Laboratory, INMEGEN, CDMX, Mexico City, Mexico.
Alma Delia Genis-MendozaGenomics of Psychiatric and Neurodegenerative Diseases Laboratory, INMEGEN, Mexico City, Mexico.
José Jaime Martínez-MagañaGenomics of Psychiatric and Neurodegenerative Diseases Laboratory, INMEGEN, Mexico City, Mexico.
Humberto NicoliniGenomics of Psychiatric and Neurodegenerative Diseases Laboratory, INMEGEN, Mexico City, Mexico.
Lorena OrozcoImmunogenomics and Metabolic Diseases Laboratory, INMEGEN, CDMX, Mexico City, Mexico.
Xavier SoberónPharmacogenomics Laboratory, INMEGEN, CDMX, Mexico City, Mexico.
National Institute of Genomic Medicine · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The identification and characterization of pharmacogenetic variants in Latin American populations is still an ongoing endeavor. Here, we investigated SNVs on genes listed by the Pharmacogenomics Knowledge Base in 1284 Mestizos and 94 Natives from Mexico. Five institutional cohorts with NGS data were retrieved from different research projects at INMEGEN, sequencing files were filtered for 55 pharmacogenes present in all cohorts to identify novel and known variation. Bioinformatic tools VEP, PROVEAN, and FATHMM were used to assess,

Indexed as

next generation sequencingpharmacodynamicspharmacogenomicspharmacokineticspopulation variation

Identifiers

PMID31649539
PMCPMC6796793
OpenAlexW2979435067

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.