Evidence map›Paper›PMID 31649673›Full record

ReviewFrontiers in immunology2019

Does B Cell Follicle Exclusion of CD8+ T Cells Make Lymph Nodes Sanctuaries of HIV Replication?

Sarah E Beck, Rebecca T Veenhuis, Joel N Blankson

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Compartmental structure in the secondary lymphoid tissue can slow downJournal of the Royal Society, Interface · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. HIV specific CD8Frontiers in immunology · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sarah E BeckDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Rebecca T VeenhuisDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Joel N BlanksonDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Project !: Differential contribution of resting CD4+ T cells and resident macrophages to viral rebound after antiretroviral treatment interruptionP01AI131306 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E · 2017 to 2021
$8.5M
Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
A mouse viral outgrowth assay for the detection of residual HIV-1 reservoirsR01AI120024 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BLANKSON, JOEL N · 2015 to 2017
$1.2M
Virus like particles as a therapeutic vaccine for HIVK01OD021323 · OD · JOHNS HOPKINS UNIVERSITY · PI BECK, SARAH · 2016 to 2020
$651k
NIAID NIH HHS P01 AI131306NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI120024NIH HHS K01 OD021323NIH HHS T32 OD011089
6 · The paper itself

Abstract

As we learn more about the HIV latent reservoir, we continue to discover that the viral reservoir is more complicated than just a pool of infected resting memory CD4+ T cells in peripheral blood. Evidence increasingly points to both certain tissues and certain types of cells as potential viral reservoirs. T follicular helper cells (T

Indexed as

B-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesGerminal CenterHIV-1HIV InfectionsHumansVirus ReplicationB cell follicle sanctuaryCD8+ lymphocytesHIVlymph nodesreservoir

Identifiers

PMID31649673
PMCPMC6794453
OpenAlexW2980257148

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.