ArticleHuman brain mapping2020
Metabolic and vascular risk factors are associated with reduced cerebral blood flow and poorer midlife memory performance.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Sleep and the Mediterranean diet: A systematic review and meta-analysis.Sleep medicine reviews · 2025Pooled it
- Low-dose nicardipine during cardiopulmonary bypass improves carotid hemodynamics in CABG patients: a randomized controlled trial.Journal of cardiothoracic surgery · 2025Trial
- The influence of blood lipids on cerebral perfusion by apolipoprotein E status.Journal of lipid research · 2026Article
- Unraveling the connection between the Mediterranean diet and sleep health: from biological mechanisms to clinical implications.Sleep & breathing = Schlaf & Atmung · 2025Review
- Associations between potential risk factors and blood-brain barrier water permeability in middle-aged and older adults.Journal of Alzheimer's disease : JAD · 2025Article
- The U.S. POINTER neurovascular ancillary study: Study design and methods.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer's continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Subclinical vascular risk composites and dementia imaging biomarkers 17-20 years later in the Multi-Ethnic Study of Atherosclerosis (MESA).Cerebral circulation - cognition and behavior · 2025Article
- Automated Quality Evaluation Index for Arterial Spin Labeling Derived Cerebral Blood Flow Maps.Journal of magnetic resonance imaging : JMRI · 2024Article
- Electrical Activity Changes and Neurovascular Unit Markers in the Brains of Patients after Cardiac Surgery: Effects of Multi-Task Cognitive Training.Biomedicines · 2024Article
- Metabolic and Vascular Risk Factor Variability Over 25 Years Relates to Midlife Brain Volume and Cognition.Journal of Alzheimer's disease : JAD · 2023Article
- Mediterranean Diet on Sleep: A Health Alliance.Nutrients · 2022Review
- Correlations Between Endocrine Hormones and Cognitive Function in Patients with Obesity: a Cross-sectional Study.Obesity surgery · 2022Article
- FGF21 response to sucrose is associated with BMI and dorsal striatal signaling in humans.Obesity (Silver Spring, Md.) · 2022Article
- The emerging neuroprotective roles of exerkines in Alzheimer's disease.Frontiers in aging neuroscience · 2022Review
- Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment.Biomedicines · 2021Review
- Obesity-induced cognitive impairment in older adults: a microvascular perspective.American journal of physiology. Heart and circulatory physiology · 2021Article
- Potential of Glucagon-Like Peptide 1 as a Regulator of Impaired Cholesterol Metabolism in the Brain.Advances in nutrition (Bethesda, Md.) · 2020Review
- Metabolic and vascular risk factors are associated with reduced cerebral blood flow and poorer midlife memory performance.Human brain mapping · 2020Article
- The relative contribution of modifiable and non-modifiable factors for determining cognition in mid-life individuals at risk for late-life Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Midlife metabolic and vascular risk factors (MVRFs) predict cognitive decline and dementia; however, these risk factors tend to overlap, and the mechanisms underlying their effects on cognitive performance are not well understood. This cross-sectional study investigates the contributions of MVRFs to regional cerebral blood flow (CBF) and verbal learning & memory among middle-aged adults. We used partial least squares (PLS) analysis to create latent risk factor profiles and examine their associations to CBF in 93 regions of interest among 451 participants (age 50.3 ± 3.5 years) of the Coronary Artery Risk Development in Young Adults. This multivariate analysis revealed regional CBF was lower in relation to obesity (higher body mass index and waist circumference), dysregulated glucose homeostasis (higher fasting glucose, oral glucose tolerance, and higher fasting insulin), and adverse fasting lipid profile (lower high-density lipoprotein cholesterol and higher triglycerides). In a sensitivity analysis, we found that significant associations between MVRFs and CBF were prominent in the hypertension-medicated subgroup. In a mediation model, the PLS-based MVRFs profile was associated with memory performance (rey auditory verbal learning test); however, CBF was not a significant mediator of this association. The results describe an adverse midlife metabolic profile that might set the stage for incipient dementia and contribute to widespread changes in CBF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.