Evidence map›Paper›PMID 31653839›Full record

ArticleNature communications2019

Dormant pathogenic CD4

Anna Cebula, Michal Kuczma, Edyta Szurek, Maciej Pietrzak, Natasha Savage, Wessam R Elhefnawy, Grzegorz Rempala, Piotr Kraj, Leszek Ignatowicz

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Autoimmunity: A New Focus on Nasal Polyps.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Effector memory CD4Science immunology · 2022
    Article
  13. Review
  14. Review
  15. The yin/yang balance of the MHC-selfFrontiers in immunology · 2022
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna CebulaInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-7868-6845
Michal KuczmaInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-2310-3590
Edyta SzurekInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Maciej PietrzakMathematical Biosciences Institute, Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-5768-7884
Natasha SavageDepartment of Pathology, Augusta University, Augusta, GA, USA.
Wessam R ElhefnawyDepartment of Computer Science, Old Dominion University, Norfolk, VA, USA.
Grzegorz RempalaMathematical Biosciences Institute, Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-6307-4555
Piotr KrajDepartment of Biological Sciences, Old Dominion University, Norfolk, VA, USA.ORCID http://orcid.org/0000-0003-2122-5105
Leszek IgnatowiczInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. lignatowicz@gsu.edu.ORCID http://orcid.org/0000-0001-8666-0381

Funding

National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7M
Antigenic specificities of intestinal CD4+Foxp3+ T cells.R01AI121151 · NIAID · GEORGIA STATE UNIVERSITY · PI IGNATOWICZ, LESZEK · 2016 to 2020
$1.9M
Modulation of Bone Morphogenic Protein signaling for cancer immunotherapyR21AI097600 · NIAID · OLD DOMINION UNIVERSITY · PI KRAJ, PIOTR J. · 2012 to 2013
$412k
NIAID NIH HHS R01 AI121151NIAID NIH HHS R21 AI097600NIH HHS P40 OD010995
6 · The paper itself

Abstract

Thymic central tolerance eliminates most immature T cells with autoreactive T cell receptors (TCR) that recognize self MHC/peptide complexes. Regardless, an unknown number of autoreactive CD4

Indexed as

AnimalsAutoantigensAutoimmunityCD4-Positive T-LymphocytesCentral ToleranceDendritic CellsForkhead Transcription FactorsHistocompatibility Antigens Class IIMiceMice, TransgenicReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaThymus GlandT-Lymphocytes, RegulatoryAutoantigensForkhead Transcription FactorsFoxp3 protein, mouseHistocompatibility Antigens Class IIReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID31653839
PMCPMC6814812

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.