Evidence map›Paper›PMID 31653960›Full record

ArticleScientific reports2019

DNA methylation of antisense noncoding RNA in the INK locus (ANRIL) is associated with coronary artery disease in a Chinese population.

Chen-Hui Zhao, Hai-Tao Cao, Jing Zhang, Qiao-Wei Jia, Feng-Hui An, Zhao-Hong Chen, Li-Hua Li, Lian-Sheng Wang, Wen-Zhu Ma, Zhi-Jian Yang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Frontiers in pharmacology · 2022
    Article
  5. Article
  6. Altered ANRIL Methylation in Epileptic Patients.Journal of molecular neuroscience : MN · 2021
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Chen-Hui ZhaoDepartment of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.
Hai-Tao CaoDepartment of Cardiovascular Medicine, the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213000, Jiangsu Province, China.
Jing ZhangDepartment of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.
Qiao-Wei JiaDepartment of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.
Feng-Hui AnDepartment of Cardiovascular Medicine, the Friendship Hospital of Ili Kazakh Autonomous Prefecture, Yining, 835000, Xinjiang, China.
Zhao-Hong ChenDepartment of Cardiovascular Medicine, the Friendship Hospital of Ili Kazakh Autonomous Prefecture, Yining, 835000, Xinjiang, China.
Li-Hua LiDepartment of Cardiovascular Medicine, the Friendship Hospital of Ili Kazakh Autonomous Prefecture, Yining, 835000, Xinjiang, China.
Lian-Sheng WangDepartment of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.
Wen-Zhu MaDepartment of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.
Zhi-Jian YangDepartment of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.
En-Zhi JiaDepartment of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. enzhijia@njmu.edu.cn.ORCID http://orcid.org/0000-0003-1354-9855
Jiangsu Province Hospital · CNYili Friendship Hospital · CNChangzhou No.2 People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore the association between methylation of antisense non-coding RNA in the INK4 locus (ANRIL) and coronary artery disease (CAD) development. Methylation levels of ANRIL in 100 subjects with CAD and 100 controls were quantitatively analyzed using Sequenom MassARRAY. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was used to identify novel pathways. Our analyses indicated that 7 to 8 CpG sites within the 2

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseAsian PeopleBase SequenceBinding SitesCoronary Artery DiseaseCpG IslandsDNA MethylationFemaleHumansMaleMiddle AgedPromoter Regions, GeneticRNA, Long NoncodingROC CurveStatistics, NonparametricCDKN2B antisense RNA, humanRNA, Long NoncodingTranscription Factors

Identifiers

PMID31653960
PMCPMC6814794
OpenAlexW2994058425

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.