Evidence map›Paper›PMID 31656546›Full record

ReviewTheranostics2019

Imaging of T-cells and their responses during anti-cancer immunotherapy.

Massis Krekorian, Gilbert O Fruhwirth, Mangala Srinivas, Carl G Figdor, Sandra Heskamp, Timothy H Witney, Erik H J G Aarntzen

Open access · goldAbstract readReview
In one paragraph

Review in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. ACS nano · 2025
    Article
  9. Review
  10. Article
  11. Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β.European journal of nuclear medicine and molecular imaging · 2024
    Article
  12. Epigenetic regulation of tumor immunity.The Journal of clinical investigation · 2024
    Review
  13. Review
  14. Advances in PET/CT Imaging for Breast Cancer.Journal of clinical medicine · 2023
    Review
  15. Review
  16. Deciphering the Relationship between SARS-CoV-2 and Cancer.International journal of molecular sciences · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Theranostics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Massis KrekorianDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Gilbert O FruhwirthDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, Kings' College London, London, United Kingdom.
Mangala SrinivasDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Carl G FigdorDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Sandra HeskampDepartment of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, The Netherlands.
Timothy H WitneyDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, Kings' College London, London, United Kingdom.
Erik H J G AarntzenDepartment of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, The Netherlands.
Radboud University Medical Center · NLKing's College London · GBRadboud University Nijmegen · NL

Funding

Cancer Research UK 21153Cancer Research UK C48390/A21153Department of HealthMedical Research CouncilWellcome Trust 107610Wellcome Trust 107610/Z/15/ZWellcome Trust 203148/Z/16/ZWellcome Trust WT 203148/Z/16/Z
6 · The paper itself

Abstract

Immunotherapy has proven to be an effective approach in a growing number of cancers. Despite durable clinical responses achieved with antibodies targeting immune checkpoint molecules, many patients do not respond. The common denominator for immunotherapies that have successfully been introduced in the clinic is their potential to induce or enhance infiltration of cytotoxic T-cells into the tumour. However, in clinical research the molecules, cells and processes involved in effective responses during immunotherapy remain largely obscure. Therefore,

Indexed as

AnimalsAntibodies, MonoclonalHumansImmunotherapyNeoplasmsT-Lymphocytes, CytotoxicAntibodies, Monoclonalcell-based therapyImmunotherapyin vivo imagingpositron emission tomographyT-cells

Identifiers

PMID31656546
PMCPMC6814447
OpenAlexW2982347600

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.