ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Dissecting the target leukocyte subpopulations of clinically relevant inflammation radiopharmaceuticals.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Establishing C-X-C motif chemokine receptor 4 as a novel imaging target in giant cell arteritis.Arthritis research & therapy · 2026Trial
- Immuno-imaging in solid organ transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Review
- Physiological uptake patterns of gastric lymph node stations onQuantitative imaging in medicine and surgery · 2026Article
- Molecular imaging of immune and fibrosis targets to guide therapy for repair after myocardial infarction.Nature reviews. Cardiology · 2026Review
- Longitudinal [European journal of nuclear medicine and molecular imaging · 2026Article
- Immunometabolism in heart failure.Nature reviews. Cardiology · 2025Review
- Radionuclide Imaging of Heart-Brain Connections.Heart failure clinics · 2025Review
- Exploring molecular imaging to investigate immune checkpoint inhibitor-related toxicity.Journal for immunotherapy of cancer · 2025Review
- Left Ventricular Remodelling Associated with the Transient Elevated [Molecular imaging and biology · 2024Article
- Radiology of fibrosis part III: genitourinary system.Journal of translational medicine · 2024Review
- Imaging Inflammation Past, Present, and Future: Focus on Cardioimmunology.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- [European journal of nuclear medicine and molecular imaging · 2023Article
- Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group.Nature reviews. Cardiology · 2023Review
- Control of the post-infarct immune microenvironment through biotherapeutic and biomaterial-based approaches.Drug delivery and translational research · 2023Review
- Tracers for Cardiac Imaging: Targeting the Future of Viable Myocardium.Pharmaceutics · 2023Review
- Radionuclide Imaging of Heart-Brain Connections.Cardiology clinics · 2023Review
- [Diagnostics (Basel, Switzerland) · 2023Article
- Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers.International journal of molecular sciences · 2022Review
- Potential novel imaging targets of inflammation in cardiac sarcoidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Review
- Systematically evaluating DOTATATE and FDG as PET immuno-imaging tracers of cardiovascular inflammation.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeukocyte subtypes bear distinct pro-inflammatory, reparative, and regulatory functions. Imaging inflammation provides information on disease prognosis and may guide therapy, but the cellular basis of the signal remains equivocal. We evaluated leukocyte subtype specificity of characterized clinically relevant inflammation-targeted radiotracers. METHODS AND
resultsLeukocyte populations were purified from blood- and THP-1-derived macrophages were polarized into M1-, reparative M2a-, or M2c-macrophages. In vitro uptake assays were conducted using tracers of enhanced glucose or amino acid metabolism and molecular markers of inflammatory cells. Both
conclusionsThe different in vitro cellular uptake profiles may allow isolation of distinct phases of the inflammatory pathway with specific inflammation-targeted radiotracers. The pathogenetic cell population in specific inflammatory diseases should be considered in the selection of an appropriate imaging agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.