Evidence map›Paper›PMID 31661294›Full record

ArticleAmerican journal of respiratory and critical care medicine2020

Exogenous Estrogen Preserves Distal Pulmonary Arterial Mechanics and Prevents Pulmonary Hypertension in Rats.

Jennifer L Philip, Diana M Tabima, Gregory D Wolf, Andrea L Frump, Tik-Chee Cheng, David A Schreier, Timothy A Hacker, Tim Lahm, Naomi C Chesler

Abstract readLetter
In one paragraph

Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Sex and gender in pulmonary arterial hypertension.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  7. Article
  8. Review
  9. Review
  10. Another Piece in the Estrogen Puzzle of Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2020
    Article
  11. Review
  12. Estradiol Metabolism: Crossroads in Pulmonary Arterial Hypertension.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jennifer L PhilipUniversity of Wisconsin-Madison College of EngineeringMadison, Wisconsin.
Diana M TabimaUniversity of Wisconsin-Madison College of EngineeringMadison, Wisconsin.
Gregory D WolfUniversity of Wisconsin-Madison College of EngineeringMadison, Wisconsin.
Andrea L FrumpIndiana University School of MedicineIndianapolis, Indianaand.
Tik-Chee ChengUniversity of Wisconsin-Madison College of EngineeringMadison, Wisconsin.
David A SchreierUniversity of Wisconsin-Madison College of EngineeringMadison, Wisconsin.
Timothy A HackerUniversity of Wisconsin-Madison School of Medicine and Public HealthMadison, Wisconsin.
Tim LahmIndiana University School of MedicineIndianapolis, Indianaand.ORCID 0000-0003-0007-6606
Naomi C CheslerUniversity of Wisconsin-Madison College of EngineeringMadison, Wisconsin.ORCID 0000-0002-7612-5796

Funding

Mechanisms of Right Ventricle Adaptation to Pulmonary HypertensionR01HL144727 · NHLBI · NATIONAL JEWISH HEALTH · PI Tim Lahm · 2019 to 2026
$4.7M
Vascular collagen accumulation & mechanical mechanisms in pulmonary hypertensionR01HL086939 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI CHESLER, NAOMI C · 2007 to 2016
$3.6M
Vascular Surgery Research Training ProgramT32HL110853 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MATSUMURA, JON STEVEN · 2012 to 2021
$2.6M
Mechanisms of right ventricle adaptation to pulmonary hypertensionR56HL134736 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHM, TIM · 2017 to 2017
$615k
Hypoxia-mediated protective estrogen receptor signaling in pulmonary hypertensionI01BX002042 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI Tim Lahm · 2014 to 2026
–
BLRD VA I01 BX002042NHLBI NIH HHS R01 HL086939NHLBI NIH HHS R01 HL144727NHLBI NIH HHS R56 HL134736NHLBI NIH HHS T32 HL110853
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBiomechanical PhenomenaEstrogensFemaleHypertension, PulmonaryPulmonary ArteryRatsRats, Sprague-DawleyEstrogens

Identifiers

PMID31661294
PMCPMC6999110

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.