Evidence map›Paper›PMID 31663450›Full record

ArticleInternational journal of immunopathology and pharmacology

Evaluation of IL6, IL10 and VDR alleles distribution in an Italian large sample of subjects affected by chronic periodontal disease.

Scapoli Luca, Carinci Francesco, Mucchi Damiano, Nota Alessandro, Caruso Silvia, Rossi Diego, Romano Michele, Severino Marco

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Scapoli LucaDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Carinci FrancescoDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Mucchi DamianoLAB SRL, Ferrara, Italy.
Nota AlessandroPaediatric Dentistry, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Caruso SilviaPaediatric Dentistry, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Rossi DiegoMaxillofacial and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Romano MicheleMaxillofacial and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Severino MarcoPaediatric Dentistry, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
University of L'Aquila · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Bologna · ITUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent decades, the role played by the immune response to bacteria in the pathogenesis of chronic periodontal disease (PD) has long been studied. Although from the clinical point of view, adequate oral hygiene is essential to ensure a satisfactory response of the host to infections, modulation of the reaction of immune system could be influenced by genetic factors. The aim of the present study was to investigate the distribution of alleles of polymorphisms relevant for chronic periodontitis in a sample of adult subjects affected by chronic PD. The present study was conducted with sample collected in Italian private practice offices from January 2013 to December 2017. The sample included 744 adult patients diagnosed with chronic periodontitis. The inclusion criteria were as follows: age > 18 years, diagnosis of chronic PD. The diagnosis of chronic periodontitis was based on the criteria established by the American Academy of Periodontology. No significant difference in allele distribution among patients from different Italian regions was found. Results, supporting absence of population heterogeneity for the investigated polymorphisms in Italy, suggest similar effect in periodontitis etiology.

Indexed as

AdultAllelesCase-Control StudiesChronic PeriodontitisFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansInterleukin-10Interleukin-6ItalyMalePolymorphism, GeneticReceptors, CalcitriolIL10 protein, humanIL6 protein, humanInterleukin-10Interleukin-6Receptors, CalcitriolVDR protein, humanchronic periodontal disease (PD)genetic susceptibilityItalian population

Identifiers

PMID31663450
PMCPMC6822182
OpenAlexW2982623767

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.