ArticleeLife2019
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Monogenic forms of inflammatory bowel disease: Genetic mechanisms, models, and clinical implications.Molecular medicine (Cambridge, Mass.) · 2026Review
- Advances in Understanding Intestinal Homeostasis: Lessons from Inflammatory Bowel Disease and Monogenic Intestinal Disorder Pathogenesis.International journal of molecular sciences · 2025Review
- Integration of signal transduction pathways in sensory epithelial enteroendocrine cells.Molecular biology of the cell · 2025Review
- Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.bioRxiv : the preprint server for biology · 2024Article
- The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated β-cell pyroptosis.Cell death discovery · 2024Article
- Dynamic changes of SCGN expression imply different phases of clear cell renal cell carcinoma progression.Discover oncology · 2024Article
- Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism.Nature metabolism · 2024Article
- Effects of acupuncture and moxibustion on ulcerative colitis: An overview of systematic reviews.Heliyon · 2024Article
- Monogenic inflammatory bowel disease-genetic variants, functional mechanisms and personalised medicine in clinical practice.Human genetics · 2023Review
- Transcriptomic Differentiation of Phenotypes in Chronic Rhinosinusitis and Its Implications for Understanding the Underlying Mechanisms.International journal of molecular sciences · 2023Article
- SCGN deficiency is a risk factor for autism spectrum disorder.Signal transduction and targeted therapy · 2023Article
- Disrupted and Elevated Circadian Secretion of Glucagon-Like Peptide-1 in a Murine Model of Type 2 Diabetes.Endocrinology · 2022Article
- Uncovering potential genes in colorectal cancer based on integrated and DNA methylation analysis in the gene expression omnibus database.BMC cancer · 2022Article
- Paneth cell-derived growth factors support tumorigenesis in the small intestine.Life science alliance · 2021Article
- Article
- Structural and mechanistic insights into secretagogin-mediated exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 4 institutions in 2 countries.
Luis F Sifuentes-DominguezDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, United States.ORCID https://orcid.org/0000-0002-9525-071X
Haiying LiDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Ernesto LlanoDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Zhe LiuKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, China.
Amika SinglaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Ashish S PatelDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, United States.
Mahesh KathaniaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Areen KhouryDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Nicholas NorrisDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, United States.
Jonathan J RiosDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, United States.
Petro StarokadomskyyDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Jason Y ParkMcDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, United States.
Purva GopalDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, United States.
Qi LiuDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Shuai TanDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Lillienne ChanDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, United States.
Theodora RossDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Steven HarrisonDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, United States.
K VenuprasadDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Linda A BakerDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID https://orcid.org/0000-0001-8272-4886
Da JiaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, China.
Ezra BursteinDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.ORCID https://orcid.org/0000-0003-4341-6367
The University of Texas Southwestern Medical Center · USSichuan University · CNSouthwestern Medical Center · USTexas Scottish Rite Hospital for Children · US
Funding
UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5MRegulation of Nutrient Homeostasis by COMMD proteinsR01DK107733 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DANIEL D BILLADEAU, Ezra Burstein · 2016 to 2026
$4.6MRole of the CCC complex in immune functionR01DK073639 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BURSTEIN, EZRA · 2007 to 2020
$3.7MANTECEDANTS SEQUELAE OF CHILDHOOD ONSET DISEASEK12HD068369 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI SKAPEK, STEPHEN X · 2011 to 2020
$3.0MPrune Belly Syndrome: Mechanisms of Filamin A MutationsR01DK127589 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BAKER, LINDA A., QIN, JUN · 2020 to 2024
$2.5MPrune Belly SyndromeR01DK105068 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BAKER, LINDA A. · 2015 to 2019
$1.8MChildren's Health Clinical Research Advisory Committee 195Eunice Kennedy Shriver National Institute of Child Health and Human Development 5 K12 HD-068369-05National Natural Science Foundation of China 91854121Natural Science Foundation of China 91854121NCATS NIH HHS UL1 TR001105NCATS NIH HHS UL1TR001105NICHD NIH HHS K12 HD068369NIDDK NIH HHS DK105068NIDDK NIH HHS R01 DK073639NIDDK NIH HHS R01 DK105068NIDDK NIH HHS R01 DK107733NIDDK NIH HHS R01 DK127589UT Southwestern Pollock Family Center for Research in Inflammatory BowelDisease
Abstract
Inflammatory bowel disease (IBD) affects 1.5-3.0 million people in the United States. IBD is genetically determined and many common risk alleles have been identified. Yet, a large proportion of genetic predisposition remains unexplained. In this study, we report the identification of an ultr arare missense variant (NM_006998.3:c.230G > A;p.Arg77His) in the
Indexed as
Genetic Predisposition to DiseaseAnimalsCell MembraneColitis, UlcerativeCytoplasmic VesiclesDisease Models, AnimalHumansMembrane FusionMiceMutation, MissenseProtein TransportSecretagoginsSNARE ProteinsSynaptosomal-Associated Protein 25SCGN protein, humanSecretagoginsSNAP25 protein, humanSNARE ProteinsSynaptosomal-Associated Protein 25genetic diseasesgeneticsgenomicshumanimmunologyinflammationinflammatory bowel diseasemouseneuroendocrine cellsscgnsnarezebrafish
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.