ArticleScientific reports2019
Maladaptive alterations of resting state cortical network in Tinnitus: A directed functional connectivity analysis of a larger MEG data set.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Tinnitus and tinnitus disorder: Genetic, neurobiological, and clinical differentiation.iScience · 2026Review
- Shared and Individual Resting-State MEG Network Signatures of Tinnitus Revealed by Holistic Graph Learning.IEEE open journal of engineering in medicine and biology · 2026Article
- Article
- Review
- Eavesdropping on Tinnitus Using MEG: Lessons Learned and Future Perspectives.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Review
- Tinnitus and Influencing Comorbidities.Laryngo- rhino- otologie · 2023Review
- Tinnitus and Multimodal Cortical Interaction.Laryngo- rhino- otologie · 2023Article
- Systems Medicine Approach for Tinnitus with Comorbid Disorders.Nutrients · 2022Article
- Utilizing Co-Creative Principles to Develop an E-Learning Platform for Interprofessional Training on Tinnitus: The Erasmus+ Project Tin-TRAC.International journal of environmental research and public health · 2022Article
- Altered cerebral blood flow in patients with unilateral venous pulsatile tinnitus: an arterial spin labeling study.The British journal of radiology · 2021Article
- [Clinical application of sound therapy in chronic subjective tinnitus].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Article
- Small-World Propensity Reveals the Frequency Specificity of Resting State Networks.IEEE open journal of engineering in medicine and biology · 2020Article
- Lateralization Effects on Cerebral Blood Flow in Patients With Unilateral Pulsatile Tinnitus Measured With Arterial Spin Labeling.Frontiers in human neuroscience · 2020Article
- Gamified Digital Solutions for Tinnitus Health Literacy: The Erasmus+ Project TinWise.Healthcare technology lettersArticle
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Authors and funding
6 authors.
Funding
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Abstract
The present study used resting state MEG whole-head recordings to identify how chronic tonal tinnitus relates to altered functional connectivity of brain's intrinsic cortical networks. Resting state MEG activity of 40 chronic tinnitus patients and 40 matched human controls was compared identifying significant alterations in intrinsic networks of the tinnitus population. Directed functional connectivity of the resting brain, at a whole cortex level, was estimated by means of a statistical comparison of the estimated phase Transfer Entropy (pTE) between the time-series of cortical activations, as reconstructed by LORETA. As pTE identifies the direction of the information flow, a detailed analysis of the connectivity differences between tinnitus patients and controls was possible. Results indicate that the group of tinnitus patients show increased connectivity from right dorsal prefrontal to right medial temporal areas. Our results go beyond previous findings by indicating that the role of the left para-hippocampal area is dictated by a modulation from dmPFC; a region that is part of the dorsal attention network (DAN), as well as implicated in the regulation of emotional processing. Additionally, this whole cortex analysis showed a crucial role of the left inferior parietal cortex, which modulated the activity of the right superior temporal gyrus, providing new hypotheses for the role of this area within the context of current tinnitus models. Overall, these maladaptive alterations of the structure of intrinsic cortical networks show a decrease in efficiency and small worldness of the resting state network of tinnitus patients, which is correlated to tinnitus distress.
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