Evidence map›Paper›PMID 31675907›Full record

ArticleJournal of diabetes science and technology2020

Critical Reappraisal of the Time-in-Range: Alternative or Useful Addition to Glycated Hemoglobin?

Lutz Heinemann, Guido Freckmann, Dirk Müller-Wieland, Monika Kellerer

Open access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Unveiling the Spectrum of Glucose Variability: A Novel Perspective on FreeStyle Libre Monitoring Data.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Time in Range Estimation in Patients with Type 2 Diabetes is Improved by Incorporating Fasting and Postprandial Glucose Levels.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lutz HeinemannScience & Co, Dusseldorf, Germany.ORCID 0000-0003-2493-1304
Guido FreckmannInstitut für Diabetes-Technologie, Ulm, Germany.ORCID 0000-0002-0406-9529
Dirk Müller-WielandKlinik für Kardiologie, Angiologie und Internistische Intensivmedizin (Med. Klinik 1), Uniklinik RWTH Aachen, Germany.
Monika KellererKlinik für Innere Medizin 1, Marienhospital Stuttgart, Germany.
Marienhospital Stuttgart · DEUniversitätsklinikum Aachen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The HbA1c value is a well-established parameter used to characterize glucose control. Continuous glucose monitoring (CGM)-derived parameters calculated using daily glucose profiles such as Time-in-Range (TiR) have increasingly been gaining interest for assessing a patient's current therapy. The question has arisen as to whether TiR could replace HbA1c? Because TiR focuses on the current quality of glucose control during a minimum of 10 to 14 days of CGM use and reflects the variability of glucose concentrations. Time-in-Range could be considered an attractive option for improving diabetes control in patients with diabetes. Due to the lack of established standards for glucose measurements with CGM systems, results from different CGM systems can deviate from each other. Time-in-Range should not be viewed as a replacement for HbA1c, but should be used to deliver valuable additional information.

Indexed as

Blood Glucose Self-MonitoringMonitoring, AmbulatoryBiomarkersBlood GlucoseDiabetes MellitusGlycated HemoglobinGlycemic ControlHumansHypoglycemic AgentsPredictive Value of TestsReproducibility of ResultsTime FactorsTreatment OutcomeBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic Agentsambulatory glucose profilecontinuous glucose monitoringHbA1cTime-in-Range

Identifiers

PMID31675907
PMCPMC7753853
OpenAlexW2984838865

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.