Evidence map›Paper›PMID 31676944›Full record

Observational studyThe international journal of cardiovascular imaging2020

Evaluation of computed tomography myocardial perfusion in women with angina and no obstructive coronary artery disease.

Daria Frestad Bechsgaard, Ida Gustafsson, Marie Mide Michelsen, Naja Dam Mygind, Kristoffer Flintholm Raft, Jesper James Linde, Klaus Fuglsang Kofoed, Fay Yu-Huei Lin, James K Min, Eva Prescott and 1 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in The international journal of cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Coronary Microvascular Dysfunction.Journal of clinical medicine · 2020
    Review
  7. Cardiovascular imaging 2019 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daria Frestad BechsgaardDepartment of Cardiology, Hvidovre University Hospital, University of Copenhagen, Kettegaard Allé 30, Hvidovre, 2650, Copenhagen, Denmark. daria.frestad@gmail.com.ORCID http://orcid.org/0000-0003-1767-4848
Ida GustafssonDepartment of Cardiology, Hvidovre University Hospital, University of Copenhagen, Kettegaard Allé 30, Hvidovre, 2650, Copenhagen, Denmark.
Marie Mide MichelsenDepartment of Cardiology, Bispebjerg University Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Naja Dam MygindDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Kristoffer Flintholm RaftDepartment of Cardiology, Bispebjerg University Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Jesper James LindeDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Klaus Fuglsang KofoedDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Fay Yu-Huei LinDalio Institute of Cardiovascular Imaging, Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medicine, New York, NY, USA.
James K MinDalio Institute of Cardiovascular Imaging, Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medicine, New York, NY, USA.
Eva PrescottDepartment of Cardiology, Bispebjerg University Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Jens Dahlgaard HoveDepartment of Cardiology, Hvidovre University Hospital, University of Copenhagen, Kettegaard Allé 30, Hvidovre, 2650, Copenhagen, Denmark.

Funding

Hjerteforeningen 11-10-R87-B-A3628-22678
6 · The paper itself

Abstract

Women with angina and no obstructive coronary artery disease (CAD) have worse cardiovascular prognosis than asymptomatic women. Limitation in myocardial perfusion caused by coronary microvascular dysfunction (CMD) is one of the proposed mechanisms contributing to the adverse prognosis. The aim of this study was to assess myocardial perfusion in symptomatic women with no obstructive CAD suspected for CMD compared with asymptomatic sex-matched controls using static CT perfusion (CTP). We performed a semi-quantitative assessment of the left ventricular myocardial perfusion and myocardial perfusion reserve (MPR), using static CTP with adenosine provocation, in 105 female patients with angina and no obstructive CAD (< 50% stenosis) and 33 sex-matched controls without a history of angina or ischemic heart disease.  Patients were on average 4 years older (p = 0.04) and had a higher burden of cardiovascular risk factors. While global perfusion during rest was comparable between the groups (age-adjusted p = 0.12), global perfusion during hyperemia was significantly reduced in patients compared with controls (163 ± 23 HU vs. 171 ± 25 HU; age-adjusted p = 0.023). The ability to increase myocardial perfusion during adenosine-induced vasodilation was significantly diminished in patients (MPR 148% vs. 158%; age-adjusted p < 0.001). This remained unchanged after adjustment for cardiovascular risk factors (p = 0.008). Women with angina and no obstructive CAD have reduced hyperemic myocardial perfusion and MPR compared with sex-matched controls. Impaired myocardial perfusion may be related to the presence of CMD in some of these women.

Indexed as

Coronary CirculationMicrocirculationMultidetector Computed TomographyAdolescentAdultAgedAged, 80 and overAngina PectorisCoronary StenosisDenmarkFemaleHumansMiddle AgedMyocardial Perfusion ImagingObserver VariationPredictive Value of TestsAngina pectorisMyocardial CT perfusion imagingMyocardial perfusion reserveStress testingWomen

Identifiers

PMID31676944

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.