ArticleHepatology (Baltimore, Md.)2020
Liver Fat and Cardiometabolic Risk Factors Among School-Age Children.
Article in Hepatology (Baltimore, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Metabolic Dysfunction-Associated Steatotic Liver Disease in Childhood: From Disease Heterogeneity to Personalized Care.Journal of personalized medicine · 2026Review
- The association between physical activity and metabolic dysfunction-associated steatotic liver disease: Evidence from the National Health and Nutrition Examination Survey and UK Biobank.The Journal of international medical research · 2026Article
- Differences in Fat Depots, Cardiometabolic Risk Factors, and Insulin Resistance Between Active and Passive School Commuters.Pediatric obesity · 2026Article
- Comparative effects of exercise modalities on ectopic fat reduction in overweight and obese children and adolescents: a narrative review.European journal of pediatrics · 2026Review
- Specific Fat Depots and Cardiometabolic Risk and Insulin Resistance in Children With Obesity.Pediatric obesity · 2026Article
- Liver Fat Is Associated With Elevated FGF21 in Youth With Obesity but Without MASLD.Pediatric obesity · 2026Article
- Sex differences in associations between body composition and cardiometabolic indicators in Chinese children: a cross-sectional study.BMJ open · 2025Article
- Symmetric dimethylguanidino valeric acid, a novel single biomarker of hepatic steatosis.iScience · 2024Article
- Review
- Review
- Sex-Related Differences in Cardiovascular Risk in Adolescents with Overweight or Obesity.Reviews in cardiovascular medicine · 2024Article
- Visceral fat and cardiometabolic future in children and adolescents: a critical update.Pediatric research · 2023Review
- Risk factors and cardio-metabolic outcomes associated with metabolic-associated fatty liver disease in childhood.EClinicalMedicine · 2023Article
- Diagnostic Performance of Biomarker-Based Scores as Predictors of Metabolic Dysfunction-Associated Fatty Liver Disease Risk in Healthy Children.Nutrients · 2023Article
- Looking beyond Cancer: Glyphosate and Liver, Metabolic Diseases in Youth.Environmental health perspectives · 2023Article
- Association between Fasting and Postprandial Levels of Liver Enzymes with Metabolic Syndrome and Suspected Prediabetes in Prepubertal Children.International journal of molecular sciences · 2023Article
- Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children.Epigenetics · 2022Article
- Body fat, pericardial fat, liver fat and arterial health at age 10 years.Pediatric obesity · 2022Article
- Ethnic disparities in liver fat accumulation in school-aged children.Obesity (Silver Spring, Md.) · 2022Observational
- Stratification by obesity class, rather than age, can identify a higher percent of children at risk for non-alcoholic fatty liver disease and metabolic dysfunction.Pediatric obesity · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
aimsNonalcoholic fatty liver disease is a major risk factor for cardiometabolic disease in adults. The burden of liver fat and associated cardiometabolic risk factors in healthy children is unknown. In a population-based prospective cohort study among 3,170 10-year-old children, we assessed whether both liver fat accumulation across the full range and nonalcoholic fatty liver disease are associated with cardiometabolic risk factors already in childhood. APPROACH AND
resultsLiver fat fraction was measured by magnetic resonance imaging, and nonalcoholic fatty liver disease was defined as liver fat fraction ≥5.0%. We measured body mass index, blood pressure, and insulin, glucose, lipids, and C-reactive protein concentrations. Cardiometabolic clustering was defined as having three or more risk factors out of high visceral fat mass, high blood pressure, low high-density-lipoprotein cholesterol or high triglycerides, and high insulin concentrations. Nonalcoholic fatty liver disease prevalences were 1.0%, 9.1%, and 25.0% among children who were normal weight, overweight, and obese, respectively. Both higher liver fat within the normal range (<5.0% liver fat) and nonalcoholic fatty liver disease were associated with higher blood pressure, insulin resistance, total cholesterol, triglycerides, and C-reactive protein concentrations (P values < 0.05). As compared with children with <2.0% liver fat, children with ≥5.0% liver fat had the highest odds of cardiometabolic clustering (odds ratio 24.43 [95% confidence interval 12.25, 48.60]). The associations remained similar after adjustment for body mass index and tended to be stronger in children who were overweight and obese.
conclusionsHigher liver fat is, across the full range and independently of body mass index, associated with an adverse cardiometabolic risk profile already in childhood. Future preventive strategies focused on improving cardiometabolic outcomes in later life may need to target liver fat development in childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.