Evidence map›Paper›PMID 31686119›Full record

ArticleCellular and molecular life sciences : CMLS2020

miR-182-5p is an evolutionarily conserved Tbx5 effector that impacts cardiac development and electrical activity in zebrafish.

Elena Guzzolino, Mario Pellegrino, Neha Ahuja, Deborah Garrity, Romina D'Aurizio, Marco Groth, Mario Baumgart, Cathy J Hatcher, Alberto Mercatanti, Monica Evangelista and 7 more

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Emerging biologic and clinical implications of miR-182-5p in gynecologic cancers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  6. Sertraline-induced 5-HT dysregulation in mouse cardiomyocytes and the impact on calcium handling.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Transcriptional factors in calcium mishandling and atrial fibrillation development.Pflugers Archiv : European journal of physiology · 2021
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 3 countries.

Elena GuzzolinoInstitute of Clinical Physiology, National Research Council, IFC via Moruzzi 1, 56124, Pisa, Italy.
Mario PellegrinoNational Institute of Optics, CNR, Pisa, Italy.
Neha AhujaDepartment of Biology, Colorado State University (CSU), Fort Collins, CO, USA.
Deborah GarrityDepartment of Biology, Colorado State University (CSU), Fort Collins, CO, USA.
Romina D'AurizioInstitute of Informatics and Telematics, CNR, Pisa, Italy.
Marco GrothThe Leibniz Institute on Aging, Fritz Lipmann Institute (FLI), Jena, Germany.
Mario BaumgartThe Leibniz Institute on Aging, Fritz Lipmann Institute (FLI), Jena, Germany.
Cathy J HatcherDepartment of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.
Alberto MercatantiInstitute of Clinical Physiology, National Research Council, IFC via Moruzzi 1, 56124, Pisa, Italy.
Monica EvangelistaInstitute of Clinical Physiology, National Research Council, IFC via Moruzzi 1, 56124, Pisa, Italy.
Chiara IppolitoDepartment of Clinical and Experimental Medicine, University of Pisa, 56126, Pisa, Italy.
Elisabetta TognoniNational Institute of Optics, CNR, Pisa, Italy.
Ryuichi FukudaDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Vincenzo LionettiInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Marco PellegriniInstitute of Informatics and Telematics, CNR, Pisa, Italy.
Federico CremisiScuola Normale Superiore, Pisa, Italy.
Letizia PittoInstitute of Clinical Physiology, National Research Council, IFC via Moruzzi 1, 56124, Pisa, Italy. l.pitto@ifc.cnr.it.ORCID http://orcid.org/0000-0002-8660-9516
Istituto di Fisiologia Clinica · ITColorado State University · USInstitute of Informatics and Telematics · ITLeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DEScuola Superiore Sant'Anna · ITMax Planck Institute for Heart and Lung Research · DEPhiladelphia College of Osteopathic Medicine · USScuola Normale Superiore · ITUniversity of Pisa · IT

Funding

American Heart Association 17AIREA33660773American Heart Association 17GRNT33460256
6 · The paper itself

Abstract

To dissect the TBX5 regulatory circuit, we focused on microRNAs (miRNAs) that collectively contribute to make TBX5 a pivotal cardiac regulator. We profiled miRNAs in hearts isolated from wild-type, CRE, Tbx5

Indexed as

AnimalsAnimals, Genetically ModifiedArrhythmias, CardiacCalciumCell LineDown-RegulationFemaleGene Expression RegulationHeartKruppel-Like Factor 4MiceMice, Inbred C57BLMicroRNAsMyocytes, CardiacPregnancyT-Box Domain ProteinsCalciumKlf4 protein, mouseKruppel-Like Factor 4MicroRNAsT-Box Domain ProteinsT-box transcription factor 5Transcription FactorsCardiac developmentHolt–Oram syndromemicroRNAsZebrafish

Identifiers

PMID31686119
PMCPMC11104936
OpenAlexW2988620017

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.