Evidence map›Paper›PMID 31690747›Full record

ArticleScientific reports2019

Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction.

Eric W Fish, Laura B Murdaugh, Chengjin Zhang, Karen E Boschen, Oswald Boa-Amponsem, Haley N Mendoza-Romero, Michael Tarpley, Lhoucine Chdid, Somnath Mukhopadhyay, Gregory J Cole and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Role of the Hedgehog Pathway in Alcohol-Induced Birth Defects.Advances in experimental medicine and biology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Is hemp (Translational animal science · 2025
    Article
  12. Article
  13. Associations of maternal alcohol and non-prescribed substance use with early child growth.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025
    Article
  14. Article
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Eric W FishBowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA.
Laura B MurdaughBowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA.
Chengjin ZhangJulius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
Karen E BoschenBowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA.
Oswald Boa-AmponsemJulius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
Haley N Mendoza-RomeroBowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA.
Michael TarpleyBiomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, USA.
Lhoucine ChdidBiomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, USA.
Somnath MukhopadhyayJulius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
Gregory J ColeJulius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
Kevin P WilliamsBiomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, USA.
Scott E ParnellBowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA. sparnell@med.unc.edu.
North Carolina Central University · USUniversity of North Carolina at Chapel Hill · US

Funding

UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Clyde W Hodge · 2003 to 2026
$46.3M
RC3 Ethanol-Cannabinoid Interaction in the Regulation of NeurogenesisU54AA019765 · NIAAA · NORTH CAROLINA CENTRAL UNIVERSITY · PI COLE, GREGORY JAY · 2010 to 2019
$8.7M
MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISMP50AA011605 · NIAAA · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI SAMULSKI, RICHARD J · 1998 to 2002
$4.9M
Exploring the Genetics of FASD in Complementary Mouse and Fish ModelsU01AA021651 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EBERHART, JOHANN K, PARNELL, SCOTT · 2012 to 2021
$3.2M
AGING AND MEMORY FOR RELATIONAL AND IMAGERIC INFORMATIONR29AG011605 · NIA · CALIFORNIA STATE UNIVERSITY FRESNO · PI SHARPS, MATTHEW J · 1994 to 1999
–
NIAAA NIH HHS P50 AA011605NIAAA NIH HHS P60 AA011605NIAAA NIH HHS U01 AA021651NIAAA NIH HHS U54 AA019765U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA-011605
6 · The paper itself

Abstract

We tested whether cannabinoids (CBs) potentiate alcohol-induced birth defects in mice and zebrafish, and explored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signaling. The CBs, Δ

Indexed as

AnimalsCannabinoidsEthanolFemaleFetal Alcohol Spectrum DisordersHedgehog ProteinsMiceReceptor, Cannabinoid, CB1Signal TransductionSmoothened ReceptorTeratogenesisCannabinoidsCNR1 protein, mouseEthanolHedgehog ProteinsReceptor, Cannabinoid, CB1Shh protein, mouseSmoothened ReceptorSmo protein, mouse

Identifiers

PMID31690747
PMCPMC6831672
OpenAlexW2984770063

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.