ArticleBrain and behavior2019
White matter hypointensities and hyperintensities have equivalent correlations with age and CSF β-amyloid in the nondemented elderly.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 85 citations in OpenAlex.
- Growth of White Matter Signal Aberrations and Cortical Changes in Men and Women: A 9-Year Multiple-Time-Point Longitudinal MRI Study in Older Adults.Human brain mapping · 2026Article
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- Estimating white matter hyperintensities volume in individuals with stroke using T1-weighted images.Neuroimage. Reports · 2026Article
- Longitudinal Changes in White Matter Hypointensities in Recurrent Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Deep optimization-guided hybrid neural network for accurate detection and segmentation of white matter hyperintensities in clinical MRI images.Scientific reports · 2026Article
- The role of brain MR and FDG-PET in the diagnosis of neurodegenerative disease.European radiology · 2026Review
- Estimating the baseline age when longitudinal changes in biomarkers accelerate: application to an imaging study of preclinical Alzheimer disease.BMC medical research methodology · 2026Article
- An explainable multimodal artificial intelligence model for classifying suicide attempters with borderline personality disorder: a pilot study.Scientific reports · 2025Article
- Regional Brain Volume Changes Across Adulthood: A Multi-Cohort Study Using MRI Data.Brain sciences · 2025Article
- Dissecting real-world memory clinical cohort heterogeneity: analysis of neuroanatomical subtypes using HYDRA.Alzheimer's research & therapy · 2025Article
- MRI signatures associated with active ischemia and disease severity in cerebral small vessel disease.Neuroimage. Reports · 2025Article
- Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum.NPJ Parkinson's disease · 2025Article
- Longitudinal behavioral and neuropsychiatric changes and their MRI correlates in predementiaJournal of Alzheimer's disease : JAD · 2025Article
- A novel approach to resilience and its links with education and Alzheimer's disease genetics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Albuminuria, structural brain findings and Circulating biomarkers of brain injury in older adults.Scientific reports · 2025Article
- Glymphatic function associates with Alzheimer's disease-signature region volumes, plasma biomarkers and white matter hyperintensity progression in cognitively unimpaired older adults.Age and ageing · 2025Article
- Dementia from Small Vessel Disease Versus Alzheimer's Disease: Separate Diseases or Distinct Manifestations of Cerebral Capillopathy Due to Blood-Brain Barrier Dysfunction? A Pilot Study.International journal of molecular sciences · 2025Article
- Use of Multiple Languages Provides Cognitive Reserve Amidst Age-Related White Matter Changes.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia.Alzheimer's research & therapy · 2025Article
- Resting-State EEG Alpha Rhythms Are Related to CSF Tau Biomarkers in Prodromal Alzheimer's Disease.International journal of molecular sciences · 2025Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
introductionT1- and T2-weighted sequences from MRI often provide useful complementary information about tissue properties. Leukoaraiosis results in signal abnormalities on T1-weighted images, which are automatically quantified by FreeSurfer, but this marker is poorly characterized and is rarely used. We evaluated associations between white matter hyperintensity (WM-hyper) volume from FLAIR and white matter hypointensity (WM-hypo) volume from T1-weighted images and compared their associations with age and cerebrospinal fluid (CSF) β-amyloid and tau.
methodsA total of 56 nondemented participants (68-94 years) were recruited and gave informed consent. All participants went through MR imaging on a GE 1.5T scanner and of these 47 underwent lumbar puncture for CSF analysis. WM-hypo was calculated using FreeSurfer analysis of T1 FSPGR 3D, and WM-hyper was calculated with the Lesion Segmentation Toolbox in the SPM software package using T2-FLAIR.
resultsWM-hyper and WM-hypo were strongly correlated (r = .81; parameter estimate (p.e.): 1.53 ± 0.15; p < .0001). Age was significantly associated with both WM-hyper (r = .31, p.e. 0.078 ± 0.030, p = .013) and WM-hypo (r = .42, p.e. 0.055 ± 0.015, p < .001). CSF β-amyloid levels were predicted by WM-hyper (r = .33, p.e. -0.11 ± 0.044, p = .013) and WM-hypo (r = .42, p.e. -0.24 ± 0.073, p = .002). CSF tau levels were not correlated with either WM-hyper (p = .9) or WM-hypo (p = .99).
conclusionsStrong correlations between WM-hyper and WM-hypo, and similar associations with age, abnormal β-amyloid, and tau suggest a general equivalence between these two imaging markers. Our work supports the equivalence of white matter hypointensity volumes derived from FreeSurfer for evaluating leukoaraiosis. This may have particular utility when T2-FLAIR is low in quality or absent, enabling analysis of older imaging data sets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.