Evidence map›Paper›PMID 31694262›Full record

ArticleMolecules (Basel, Switzerland)2019

Novel C7-Substituted Coumarins as Selective Monoamine Oxidase Inhibitors: Discovery, Synthesis and Theoretical Simulation.

Dong Wang, Ren-Yuan Hong, Mengyao Guo, Yi Liu, Nianhang Chen, Xun Li, De-Xin Kong

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dong WangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.
Ren-Yuan HongKey Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan 250012, Shandong, China.
Mengyao GuoAgricultural Bioinformatics Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
Yi LiuAgricultural Bioinformatics Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
Nianhang ChenAgricultural Bioinformatics Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
Xun LiInstitute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, No 18877, Jingshi Road, Ji'nan 250002, Shandong, China.ORCID 0000-0002-5582-8628
De-Xin KongState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0003-0744-116X
Huazhong Agricultural University · CNShandong First Medical University · CNShandong University · CN

Funding

Fundamental Research Funds for the Central Universities 2662017PY117National Natural Science Foundation of China 21275061Natural Science Foundation of Shandong Province ZR2018MH042
6 · The paper itself

Abstract

There is a continued need to develop new selective human monoamine oxidase (

Indexed as

BrainCaco-2 CellsCell Line, TumorCoumarinsHumansMolecular Docking SimulationMonoamine OxidaseMonoamine Oxidase InhibitorsProtein BindingStructure-Activity RelationshipCoumarinsMonoamine OxidaseMonoamine Oxidase InhibitorsBRS-3Din silico pharmacokinetic predictionsmolecular dynamic simulationsmonoamine oxidase (MAO) inhibitorssubtype selectivity

Identifiers

PMID31694262
PMCPMC6864482
OpenAlexW2988643801

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.