Evidence map›Paper›PMID 31707449›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2020

Metallothionein induction attenuates the progression of lung injury in mice exposed to long-term intermittent hypoxia.

Xingyu Lin, Rekha Jagadapillai, Jun Cai, Lu Cai, Guoguang Shao, Evelyne Gozal

Abstract read
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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
  5. Review
  6. Article
  7. The role of NMDA glutamate receptors in lung injury caused by chronic long-term intermittent hypobaric hypoxia.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xingyu LinDepartment of Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China.
Rekha JagadapillaiPRI, Departments of Pediatrics, University of Louisville, 570, S. Preston St., Ste 321, Louisville, 40202, USA.
Jun CaiPRI, Departments of Pediatrics, University of Louisville, 570, S. Preston St., Ste 321, Louisville, 40202, USA.
Lu CaiPRI, Departments of Pediatrics, University of Louisville, 570, S. Preston St., Ste 321, Louisville, 40202, USA.
Guoguang Shao *Department of Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China. guoguangshao@sohu.com.
Evelyne Gozal *PRI, Departments of Pediatrics, University of Louisville, 570, S. Preston St., Ste 321, Louisville, 40202, USA. evelyne.gozal@louisville.edu.ORCID http://orcid.org/0000-0001-7451-087X
University of Louisville · USJilin University · CN

Funding

Sleep Research Society Foundation/J. Christian Gillin M.D. 001GN09
6 · The paper itself

Abstract

backgroundIntermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), is prevalent in older adults and associated with inflammation. We previously showed that IH induces renal fibrosis and cardiomyopathy and hypothesized that lung inflammatory changes may underlie deficits in pulmonary function in OSA.

methodsPulmonary inflammatory and oxidative markers were assessed in metallothionein KO (MT-KO) mice and WT 129S1 controls exposed to IH or to normoxia for 8 weeks.

resultsMT expression increased at 3 days in WT, falling back at 1 week. Pro-fibrotic markers CTGF and PAI-1 were unchanged in WT, but increased at 3 or 8 weeks, with enhanced Sirius Red staining at 8 weeks, in IH-exposed MT-KO. Cellular infiltration, TNF-α and IL-6 increased earlier in IH-exposed MT-KO than in WT. Oxidative markers, 3-nitrotyrosine and 4-hydroxynonenal increased in both but persisted in MT-KO. Antioxidant Nrf2, HO-1 and NQO1, increased at 3 days in WT mice and at 8 weeks IH in MT-KO. While early Nrf2 induction required MT, its later increase at 8 weeks in MT-KO was independent from MT.

conclusionsWe conclude that early MT and antioxidant gene response protects from fibrotic changes in long-term IH-exposed mouse lung. Without this response, pulmonary fibrosis may develop with longer IH exposure.

Indexed as

AnimalsHypoxiaInterleukin-6LungLung InjuryMetallothioneinMice, KnockoutOxidative StressTumor Necrosis Factor-alphaInterleukin-6interleukin-6, mouseMetallothioneinTnf protein, mouseTumor Necrosis Factor-alphaIntermittent hypoxiaLung inflammationMetallothioneinObstructive sleep apneaOxidative injury

Identifiers

PMID31707449
OpenAlexW2986383509

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.