Evidence map›Paper›PMID 31709889›Full record

ArticlePhysiological genomics2019

Effect of

Akash K George, Rubens P Homme, Avisek Majumder, Suresh C Tyagi, Mahavir Singh

Open access · bronzeAbstract read
In one paragraph

Article in Physiological genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Akash K GeorgeEye and Vision Science Laboratory, Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky.
Rubens P HommeEye and Vision Science Laboratory, Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky.
Avisek MajumderDepartment of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.
Suresh C TyagiDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky.
Mahavir SinghEye and Vision Science Laboratory, Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky.
University of Louisville · USUniversity of California, San Francisco · US

Funding

FOCUS Data Coordinating CenterU01HL074815 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L · 2003 to 2010
$2.9M
Mechanisms of Mitochondrial Dysfunction in Brain VasculatureR01HL107640 · NHLBI · UNIVERSITY OF LOUISVILLE · PI TYAGI, NEETU · 2012 to 2016
$1.8M
NHLBI NIH HHS R01 HL107640NHLBI NIH HHS U01 HL074815
6 · The paper itself

Abstract

Retinal degeneration from inherited gene mutation(s) is a common cause of blindness because of structural and functional alterations in photoreceptors. Accordingly, various approaches are being tested to ameliorate or even cure neuroretinal blinding conditions in susceptible patients by employing neuroprotective agents, gene therapeutics, optogenetics, regenerative therapies, and retinal prostheses. The FVB/NJ mouse strain inherently has a common

Indexed as

AnimalsDisease Models, AnimalFemaleGene Knockout TechniquesHomeostasisMaleMatrix Metalloproteinase 9MiceMice, Inbred C57BLMice, KnockoutRetinaRetinal DegenerationTissue Inhibitor of Metalloproteinase-1Vascular RemodelingVision, OcularMatrix Metalloproteinase 9Mmp9 protein, mouseTimp1 protein, mouseTissue Inhibitor of Metalloproteinase-1blindnessextracellular matrixretinavascular remodelingvision loss

Identifiers

PMID31709889
PMCPMC6962592
OpenAlexW2986776355

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.