Evidence map›Paper›PMID 31710686›Full record

ArticleCardiovascular research2020

Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide.

Tetsuo Horimatsu, Andra L Blomkalns, Mourad Ogbi, Mary Moses, David Kim, Sagar Patel, Nicole Gilreath, Lauren Reid, Tyler W Benson, Jonathan Pye and 14 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Review
  6. Article
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  12. Article
  13. The Role of NADAmerican journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
    Review
  14. Mitochondrial NADNature cardiovascular research · 2025
    Article
  15. Article
  16. Review
  17. Targeted NADJournal of controlled release : official journal of the Controlled Release Society · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 2 countries.

Tetsuo HorimatsuDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Andra L BlomkalnsDepartment of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Mourad OgbiDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Mary MosesDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
David KimDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Sagar PatelDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Nicole GilreathDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Lauren ReidDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Tyler W BensonDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Jonathan PyeDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Samah AhmadiehDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Allie ThompsonDepartment of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Nathan RobbinsDepartment of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Adrien MannDepartment of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ashlee EdgellDepartment of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Stephanie BenjaminDepartment of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Brian K StansfieldDepartment of Vascular Biology Center, Medical College of Georgia, Augusta University, 1459 Laney Walker Blvd, Augusta, GA 30912, USA.
Yuqing HuoDepartment of Vascular Biology Center, Medical College of Georgia, Augusta University, 1459 Laney Walker Blvd, Augusta, GA 30912, USA.
David J FultonDepartment of Vascular Biology Center, Medical College of Georgia, Augusta University, 1459 Laney Walker Blvd, Augusta, GA 30912, USA.
Gautam AgarwalDepartment of Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Nagendra SinghBiochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Stefan OffermannsDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Ludwigstraße, Bad Nauheim, Germany.
Neal L WeintraubDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Ha Won KimDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Augusta University · USUniversity of Cincinnati Medical Center · USMax Planck Institute for Heart and Lung Research · DE

Funding

NEI NIH HHS R01 EY029318NHLBI NIH HHS R01 HL126949NHLBI NIH HHS R01 HL134354NHLBI NIH HHS R01 HL142097NIAMS NIH HHS R01 AR070029
6 · The paper itself

Abstract

aimsChronic adventitial and medial infiltration of immune cells play an important role in the pathogenesis of abdominal aortic aneurysms (AAAs). Nicotinic acid (niacin) was shown to inhibit atherosclerosis by activating the anti-inflammatory G protein-coupled receptor GPR109A [also known as hydroxycarboxylic acid receptor 2 (HCA2)] expressed on immune cells, blunting immune activation and adventitial inflammatory cell infiltration. Here, we investigated the role of niacin and GPR109A in regulating AAA formation. METHODS AND

resultsMice were supplemented with niacin or nicotinamide, and AAA was induced by angiotensin II (AngII) infusion or calcium chloride (CaCl2) application. Niacin markedly reduced AAA formation in both AngII and CaCl2 models, diminishing adventitial immune cell infiltration, concomitant inflammatory responses, and matrix degradation. Unexpectedly, GPR109A gene deletion did not abrogate the protective effects of niacin against AAA formation, suggesting GPR109A-independent mechanisms. Interestingly, nicotinamide, which does not activate GPR109A, also inhibited AAA formation and phenocopied the effects of niacin. Mechanistically, both niacin and nicotinamide supplementation increased nicotinamide adenine dinucleotide (NAD+) levels and NAD+-dependent Sirt1 activity, which were reduced in AAA tissues. Furthermore, pharmacological inhibition of Sirt1 abrogated the protective effect of nicotinamide against AAA formation.

conclusionNiacin protects against AAA formation independent of GPR109A, most likely by serving as an NAD+ precursor. Supplementation of NAD+ using nicotinamide-related biomolecules may represent an effective and well-tolerated approach to preventing or treating AAA.

Indexed as

Angiotensin IIAnimalsAorta, AbdominalAortic Aneurysm, AbdominalCalcium ChlorideCells, CulturedDilatation, PathologicDisease Models, AnimalMaleMice, Inbred C57BLMice, KnockoutNADNiacinNiacinamideReceptors, G-Protein-CoupledReceptors, LDLAngiotensin IICalcium ChlorideHcar2 protein, mouseNADNiacinNiacinamideReceptors, G-Protein-CoupledReceptors, LDLSirt1 protein, mouseSirtuin 1Abdominal aortic aneurysmGPR109ANAD+NicotinamideNicotinic acidSirt1

Identifiers

PMID31710686
PMCPMC7695356
OpenAlexW2988568802

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.