Evidence map›Paper›PMID 31711513›Full record

Trial reportJournal of translational medicine2019

Autologous adipose-derived stromal cell treatment for patients with refractory angina (MyStromalCell Trial): 3-years follow-up results.

Abbas Ali Qayyum, Anders Bruun Mathiasen, Steffen Helqvist, Erik Jørgensen, Mandana Haack-Sørensen, Annette Ekblond, Jens Kastrup

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01449032 (MesenchYmal STROMAL CELL Therapy in Patients With Chronic Myocardial Ischemia), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01449032 phase2completednot on this map

MesenchYmal STROMAL CELL Therapy in Patients With Chronic Myocardial Ischemia (MyStromalCell Trial)

TypeinterventionalSponsorRigshospitalet, DenmarkRan2010 to 2014Enrolled60ConditionsChronic Ischemic Heart DiseaseArmsMSC, Saline
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Abbas Ali QayyumDepartment of Cardiology & Cardiac Catheterization Laboratory 2014, Rigshospitalet University of Copenhagen, Inge Lehmanns Vej 7, 2100, Copenhagen, Denmark. abbas.ali.qayyum@regionh.dk.ORCID 0000-0002-1620-0002
Anders Bruun MathiasenDepartment of Cardiology & Cardiac Catheterization Laboratory 2014, Rigshospitalet University of Copenhagen, Inge Lehmanns Vej 7, 2100, Copenhagen, Denmark.
Steffen HelqvistDepartment of Cardiology & Cardiac Catheterization Laboratory 2014, Rigshospitalet University of Copenhagen, Inge Lehmanns Vej 7, 2100, Copenhagen, Denmark.
Erik JørgensenDepartment of Cardiology, Gentofte University of Copenhagen, Kildegårdsvej 28, 2900, Hellerup, Denmark.
Mandana Haack-SørensenCardiology Stem Cell Centre 9302, Rigshospitalet University of Copenhagen, Henrik Harpestrengsvej 4C, 2100, Copenhagen, Denmark.
Annette EkblondCardiology Stem Cell Centre 9302, Rigshospitalet University of Copenhagen, Henrik Harpestrengsvej 4C, 2100, Copenhagen, Denmark.
Jens KastrupDepartment of Cardiology & Cardiac Catheterization Laboratory 2014, Rigshospitalet University of Copenhagen, Inge Lehmanns Vej 7, 2100, Copenhagen, Denmark.
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStem cell therapy is investigated as a treatment option for patients with ischemic heart disease. In this study, long-term safety and efficacy of autologous intra-myocardial injections of adipose-derived stromal cells (ASCs) was studied in patients with refractory angina.

methodsSixty patients with coronary artery stenosis and preserved left ventricular ejection fraction were 2:1 randomised to intramyocardial injections of ASCs or saline and followed for 3 years.

resultsFor patients in the ASC group, the bicycle exercise time and the exercise performance in watt were un-changed (383 ± 30 s to 370 ± 44 s, P = 0.052 and 81 ± 6 to 78 ± 10, P = 0.123, respectively), but the performance in METs was reduced significantly (4.2 ± 0.3 to 4.0 ± 0.4, P = 0.027) during the follow-up period. However, in the same period, there was in the placebo group a significant decline in bicycle exercise time (437 ± 53 s to 383 ± 58 s, P = 0.001), the exercise performance measured in watt (87 ± 12 W to 80 ± 12 W, P = 0.019) and in METs (4.5 ± 0.4 to 4.1 ± 0.4, P = 0.002). Moreover, angina measured as CCS class was significantly reduced in the ASC group but not in the placebo group (2.5 ± 0.9 to 1.8 ± 1.2, P = 0.002 and 2.5 ± 0.8 to 2.1 ± 1.3, P = 0.186, respectively). However, no significant change was observed between the two groups.

conclusionsPatients receiving ASCs had improved cardiac symptoms and unchanged exercise capacity, in opposition to deterioration in the placebo group. Trial registration ClinicalTrials.gov Identifier: NCT01449032. Registered 7 October 2011-Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT01449032?term=jens+kastrup&rank=7.

Indexed as

AdultAgedAged, 80 and overAngina PectorisAutograftsCell Culture TechniquesCell SeparationDouble-Blind MethodExercise TestFemaleFollow-Up StudiesHumansInjectionsMaleMesenchymal Stem Cell TransplantationMiddle AgedAdipose derived stromal cellsChronic ischemic heart diseaseRefractory anginaRegenerationStem cell therapy

Identifiers

PMID31711513
PMCPMC6849216
OpenAlexW2987143453

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.