Evidence map›Paper›PMID 31712313›Full record

ArticleThe Journal of biological chemistry2019

Template-switching mechanism of a group II intron-encoded reverse transcriptase and its implications for biological function and RNA-Seq.

Alfred M Lentzsch, Jun Yao, Rick Russell, Alan M Lambowitz

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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  7. Review
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  9. Detection of piRNA-54265 in human serum: evidence and significance.Cancer communications (London, England) · 2023
    Article
  10. Review
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alfred M LentzschInstitute for Cellular and Molecular Biology, Departments of Molecular Biosciences and Oncology, University of Texas at Austin, Austin, Texas 78712.
Jun YaoInstitute for Cellular and Molecular Biology, Departments of Molecular Biosciences and Oncology, University of Texas at Austin, Austin, Texas 78712.
Rick RussellInstitute for Cellular and Molecular Biology, Departments of Molecular Biosciences and Oncology, University of Texas at Austin, Austin, Texas 78712.
Alan M LambowitzInstitute for Cellular and Molecular Biology, Departments of Molecular Biosciences and Oncology, University of Texas at Austin, Austin, Texas 78712 lambowitz@austin.utexas.edu.ORCID 0000-0001-6036-2423
The University of Texas at Austin · US

Funding

RETROPLASMID AND GROUP II INTRON REVERSE TRANSCRIPTASESR01GM037949 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI LAMBOWITZ, ALAN M. · 1986 to 2019
$8.6M
Mechanisms and Specificity of Proteins that Manipulate DNA and RNA StructureR35GM131777 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Rick Russell · 2019 to 2026
$3.2M
NIGMS NIH HHS R01 GM037949NIGMS NIH HHS R35 GM131777
6 · The paper itself

Abstract

The reverse transcriptases (RTs) encoded by mobile group II introns and other non-LTR retroelements differ from retroviral RTs in being able to template-switch efficiently from the 5' end of one template to the 3' end of another with little or no complementarity between the donor and acceptor templates. Here, to establish a complete kinetic framework for the reaction and to identify conditions that more efficiently capture acceptor RNAs or DNAs, we used a

Indexed as

IntronsTemplates, GeneticAnimalsDNA PrimersDNA Transposable ElementsExome SequencingGenetic Complementation TestInsectaKineticsNucleotidesRetroelementsRetroviridaeRNARNA-Directed DNA PolymeraseRNA-SeqTemperatureDNA PrimersDNA Transposable ElementsNucleotidesRetroelementsRNARNA-Directed DNA Polymerasechemical biologyDNA sequencingenzyme kineticsgroup II intron reverse transcriptasenon-templated nucleotide additionretrovirusreverse transcriptionRNARNA-dependent RNA polymeraseRNA sequencingRNA virusstructure–functionthermostable group II intron reverse transcriptasetransposable element (TE)viral polymerase

Identifiers

PMID31712313
PMCPMC6926447
OpenAlexW2988461472

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.