Evidence map›Paper›PMID 31714683›Full record

ArticleJournal of cellular and molecular medicine2020

Deletion of the FHL2 gene attenuates intima-media thickening in a partially ligated carotid artery ligated mouse model.

Chi-Yu Chen, Hsiao-Ya Tsai, Shih-Hung Tsai, Pao-Hsien Chu, Po-Hsun Huang, Jaw-Wen Chen, Shing-Jong Lin

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chi-Yu ChenInstitute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.ORCID 0000-0003-1245-0888
Hsiao-Ya TsaiInstitute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Shih-Hung TsaiDepartment of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Pao-Hsien ChuFirst Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.
Po-Hsun HuangInstitute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.ORCID 0000-0003-1584-6749
Jaw-Wen ChenDivision of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan.
Shing-Jong LinInstitute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
National Yang Ming Chiao Tung University · TWChang Gung University · TWTri-Service General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The four and a half LIM domain protein 2 (FHL2) is a member of the four and a half LIM domain (FHL) gene family, and it is associated with cholesterol-enriched diet-promoted atherosclerosis. However, the effect of FHL2 protein on vascular remodelling in response to hemodynamic alterations remains unclear. Here, we investigated the role of FHL2 in a model of restricted blood flow-induced atherosclerosis. To promote neointimal hyperplasia in vivo, we subjected FHL2

Indexed as

Carotid Intima-Media ThicknessGene DeletionAnimalsAtherosclerosisCarotid ArteriesCell MovementCell ProliferationCells, CulturedLIM-Homeodomain ProteinsMiceMice, Inbred C57BLMice, KnockoutMuscle ProteinsMuscle, Smooth, VascularSignal TransductionTranscription FactorsFhl2 protein, mouseLIM-Homeodomain ProteinsMuscle ProteinsTranscription Factorscarotid artery ligationFHL2neointimal hyperplasiasmooth muscle cell

Identifiers

PMID31714683
PMCPMC6933399
OpenAlexW2986217829

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.