ArticleCancer medicine2020
Large retroperitoneal lymphadenopathy and increased risk of venous thromboembolism in patients receiving first-line chemotherapy for metastatic germ cell tumors: A study by the global germ cell cancer group (G3).
Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Thromboembolic disease in testicular germ cell tumors-real-world evidence of three Portuguese institutions.Frontiers in oncology · 2026Article
- Risk Factors for Arterial Thromboembolic Events in Male Germ Cell Tumors Treated with Chemotherapy.Cancers · 2025Article
- Simple, Effective and Validated. VTE CASE Risk Assessment Score for Venous Thromboembolism in Metastatic Germ Cell Tumour Patients Before First-Line Chemotherapy.Cancer medicine · 2024Article
- Simple yet (more?) effective. Venous thromboembolism risk assessment model for germ cell tumour patients receiving first-line chemotherapy.Cancer medicine · 2023Article
- Cardiovascular Risks in Testicular Cancer: Assessment, Prevention, and Treatment.Current oncology reports · 2023Review
- Canadian Urological Association consensus guideline: Management of testicular germ cell cancer.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022Article
- Incidence and patient characteristics of venous thromboembolism during neoadjuvant chemotherapy for ovarian cancer.Journal of thrombosis and thrombolysis · 2022Article
- Thromboembolic Events During Treatment with Cisplatin-based Chemotherapy in Metastatic Testicular Germ-cell Cancer 2000-2014: A Population-based Cohort Study.European urology open science · 2021Article
- Thromboembolic events in metastatic testicular cancer treated with cisplatin-based chemotherapy.World journal of clinical oncology · 2021Article
- Prophylaxis Against Thromboembolic Events During Chemotherapy for Germ Cell Cancer.Frontiers in oncology · 2021Review
- Article
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetastatic germ cell tumor (mGCT) patients receiving chemotherapy have increased risk of life-threatening venous thromboembolism (VTE). Identifying VTE risk factors may guide thromboprophylaxis in this highly curable population.
methodsData were collected from mGCT patients receiving first-line platinum-based chemotherapy at 22 centers. Predefined variables included International Germ Cell Cancer Collaborative Group (IGCCCG) risk classification, long-axis diameter of largest retroperitoneal lymph node (RPLN), Khorana score, and use of indwelling vascular access device (VAD). VTE occurring at baseline, during chemotherapy and within 90 days, was analyzed.
resultsData from 1135 patients were collected. Median age was 31 years (range 10-74). IGCCCG risk was 64% good, 20% intermediate, and 16% poor. VTE occurred in 150 (13%) patients. RPLN >3.5 cm demonstrated highest discriminatory accuracy for VTE (AUC 0.632, P < .001) and was associated with significantly higher risk of VTE in univariable analysis (22% vs 8%, OR 3.0, P < .001) and multivariable analysis (OR 1.8, P = .02). Other significant risk factors included, Khorana score ≥3 (OR 2.6, P = .008) and VAD use (OR 2.7, P < .001).
conclusionsLarge RPLN and VAD use are independent risk factors for VTE in mGCT patients receiving chemotherapy. VAD use should be minimized in this population and thromboprophylaxis might be considered for large RPLN.
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