ReviewMetabolic engineering communications2019
Advances in the development and application of microbial consortia for metabolic engineering.
Review in Metabolic engineering communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed.
- Genomic insights into the metabolic complementarity of a synthetic marine consortium for hydrocarbon degradation in coastal sand microcosms.Biodegradation · 2026Article
- Different co-culture approaches to increase metabolites in foods.Food science and biotechnology · 2026Review
- Research Progress Review on the Activation of Bioactive Substances by Targeted Fermentation of Rice Bran.Foods (Basel, Switzerland) · 2026Review
- Direct valorization of agricultural byproducts to vanillin by a synergistic Komagataella phaffii co-culture system.Biotechnology for biofuels and bioproducts · 2026Article
- Burden-aware feedback control of microbial consortia.Nature communications · 2026Article
- Construction of microbial systems for polyethylene terephthalate degradation.Synthetic and systems biotechnology · 2025Review
- Comprehensive heavy metal remediation mechanisms with insights into CRISPR-Cas9 and biochar innovations.Biodegradation · 2025Review
- Investigating the Potential of Division of Labor in Synthetic Bacterial Communities for the Production of Violacein.ACS synthetic biology · 2025Article
- Review
- Integration of co-culture and transport engineering for enhanced metabolite production.Plant biotechnology (Tokyo, Japan) · 2024Article
- Microbial Consortia: Promising Tool as Plant Bioinoculants for Agricultural Sustainability.Current microbiology · 2024Review
- Efficient Biosynthesis of Salidroside via ArtificialACS omega · 2024Article
- Programming Dynamic Division of Labor Using Horizontal Gene Transfer.ACS synthetic biology · 2024Article
- Spontaneously established syntrophic yeast communities improve bioproduction.Nature chemical biology · 2023Article
- Developing rumen mimicry process for biological ammonia synthesis.Bioprocess and biosystems engineering · 2023Article
- A thermophilic chemolithoautotrophic bacterial consortium suggests a mutual relationship between bacteria in extreme oligotrophic environments.Communications biology · 2023Article
- Metabolic engineering using acetate as a promising building block for the production of bio-based chemicals.Engineering microbiology · 2022Review
- Tailoring the Optimized Fermentation Conditions of SCOBY-Based Membranes and Milk Kefir Grains to Promote Various Functional Properties.Foods (Basel, Switzerland) · 2022Article
- Chaos in synthetic microbial communities.PLoS computational biology · 2022Article
- Controlling microbial co-culture based on substrate pulsing can lead to stability through differential fitness advantages.PLoS computational biology · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in metabolic engineering enable the production of high-value chemicals via expressing complex biosynthetic pathways in a single microbial host. However, many engineered strains suffer from poor product yields due to redox imbalance and excess metabolic burden, and require compartmentalization of the pathway for optimal function. To address this problem, significant developments have been made towards co-cultivation of more than one engineered microbial strains to distribute metabolic burden between the co-cultivation partners and improve the product yield. In this emerging approach, metabolic pathway modules can be optimized separately in suitable hosts that will then be combined to enable optimal functionality of the complete pathway. This modular approach broadens the possibilities to fine tune sophisticated production platforms and thus achieve the biosynthesis of very complex compounds. Here, we review the different applications and the overall potential of natural and artificial co-cultivation systems in metabolic engineering in order to improve bioproduction/bioconversion. In addition to the several advantages over monocultures, major challenges and opportunities associated with co-cultivation are also discussed in this review.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.