Evidence map›Paper›PMID 31721163›Full record

ArticleBritish journal of pharmacology2020

β

Isabel Silva, M Teresa Magalhães-Cardoso, Fátima Ferreirinha, Sílvia Moreira, Ana Filipa Costa, Diogo Silva, Cátia Vieira, Miguel Silva-Ramos, Paulo Correia-de-Sá

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Presynaptic Adrenoceptors.Handbook of experimental pharmacology · 2024
    Review
  4. Article
  5. Article
  6. Selective reduction of neurotransmitter release by cAMP-dependent pathways in mouse detrusor.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  7. Review
  8. βBritish journal of pharmacology · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Isabel SilvaLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.
M Teresa Magalhães-CardosoLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.
Fátima FerreirinhaLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.
Sílvia MoreiraLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.
Ana Filipa CostaLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.
Diogo SilvaLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.
Cátia VieiraLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.
Miguel Silva-RamosLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.
Paulo Correia-de-SáLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.ORCID 0000-0002-6114-9189
Universidade do Porto · PT

Funding

Associação Portuguesa de UrologiaFundação para a Ciência e a Tecnologia Pest-OE/SAU/UI215/2014Fundação para a Ciência e a Tecnologia PTDC/SAU-OSM/104369/2008Fundação para a Ciência e a Tecnologia REEQ/1168/SAU/2005Fundação para a Ciência e a Tecnologia REEQ/1264/SAU/2005Fundação para a Ciência e a Tecnologia SFRH/BD/88855/2012Fundação para a Ciência e a Tecnologia UID/BIM/4308/2016Fundação para a Ciência e a Tecnologia UID/BIM/4308/2019University of Porto/Caixa Geral de Depósitos (Investigação Científica na Pré-Graduação)
6 · The paper itself

Abstract

background and purposeThe mechanism by which β EXPERIMENTAL APPROACH: [ KEY

resultsThe exchange protein directly activated by cAMP (EPAC) inhibitor, ESI-09, prevented mirabegron- and isoprenaline-induced adenosine release from human and rat detrusor strips respectively. ESI-09, but not the PKA inhibitor, H-89, attenuated inhibition of [ CONCLUSION AND IMPLICATIONS: Data suggest that β

Indexed as

AdenosineUrinary BladderAnimalsCholinergic AgentsCyclic AMPHumansRatsReceptors, AdrenergicAdenosineCholinergic AgentsCyclic AMPReceptors, Adrenergic

Identifiers

PMID31721163
PMCPMC7060368
OpenAlexW2985817627

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.