Evidence map›Paper›PMID 31722770›Full record

ArticleEpidemiology and psychiatric sciences2019

Alzheimer's disease medication and outcomes of hospitalisation among patients with dementia.

T Möllers, L Perna, H Stocker, P Ihle, I Schubert, B Schöttker, L Frölich, J Bauer, H Brenner

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and psychiatric sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06805578 (Exploring and Evaluating the Impact of 'Refresh and Reconnect!'), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06805578 nacompletednot on this mapstarted 2025, after this paper: background citation

Exploring and Evaluating the Impact of 'Refresh and Reconnect!': A Museum-based Heritage Programme for Older Persons With Cognitive Impairment

TypeinterventionalSponsorDuke-NUS Graduate Medical SchoolRan2025 to 2026Enrolled108ConditionsMild Cognitive Impairment (MCI), Ageing, Mild Dementia, Well-beingArmsHeritage art programme
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

T MöllersNetwork Aging Research, Heidelberg University, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-1833-2412
L PernaDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
H StockerNetwork Aging Research, Heidelberg University, Heidelberg, Germany.
P IhlePMV Research Group, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
I SchubertPMV Research Group, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
B SchöttkerNetwork Aging Research, Heidelberg University, Heidelberg, Germany.
L FrölichDepartment of Gerontopsychiatry, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany.
J BauerNetwork Aging Research, Heidelberg University, Heidelberg, Germany.
H BrennerNetwork Aging Research, Heidelberg University, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe use of Alzheimer disease medication for the treatment of dementia symptoms has shown significant benefits with regards to functional and cognitive outcomes as well as nursing home placement (NHP) and mortality. Hospitalisations in these patient groups are characterised by extended length of stays (LOS), frequent readmissions, frequent NHP and high-mortality rates. The impact of Alzheimer disease medication on the aforementioned outcomes remains still unknown. This study assessed the association of Alzheimer disease medication with outcomes of hospitalisation among patients with Alzheimer disease and other forms of dementia.

methodsA dynamic retrospective cohort study from 2004 to 2015 was conducted which claims data from a German health insurance company. People with dementia (PWD) were identified using ICD-10 codes and diagnostic measures. The main predictor of interest was the use of Alzheimer disease medication. Hospitalisation outcomes included LOS, readmissions, NHP and mortality during and after hospitalisation across four hospitalisations. Confounding was addressed using a propensity score throughout all analyses.

resultsA total of 1380 users of Alzheimer disease medication and 6730 non-users were identified. The use of Alzheimer disease medication was associated with significantly shorter LOS during the first hospitalisations with estimates for the second, third and fourth showed a tendency towards shorter hospital stays. In addition, current users of Alzheimer disease medication had a lower risk of hospital readmission after the first two hospitalisations. These associations were not significant for the third and fourth hospitalisations. Post-hospitalisation NHP and mortality rates also tended to be lower among current users than among non-users but differences did not reach statistical significance.

conclusionsOur results indicate that Alzheimer disease medication might contribute to a reduction of the LOS and the number of readmissions in PWD.

Indexed as

AgedAlzheimer DiseaseDementiaFemaleHospitalizationHumansLength of StayMaleNursing HomesPatient ReadmissionPrognosisRetrospective StudiesAlzheimer's diseaseDementiaepidemiologyprospective studypsychopharmacology

Identifiers

PMID31722770
PMCPMC8060969

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.