GLP-1 receptor agonists × cardiovascular events

SynthesisMedicine2019

Cardiovascular outcomes of liraglutide in patients with type 2 diabetes: A systematic review and meta-analysis.

Chun-Mei Duan et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 14,608 people · 2019

Randomised comparison

Reduced cardiovascular events

−11%−18% to −4%

Bigger than 2 in 10 for cardiovascular events

As reported

RR 0.89, 95% CI 0.82–0.96

Randomised comparison

Reduced cardiovascular events

−15%−26% to −1%

Bigger than 3 in 10 for cardiovascular events

As reported

RR 0.85, 95% CI 0.74–0.99

Randomised comparison

Reduced cardiovascular events

−16%−26% to −4%

Bigger than 3 in 10 for cardiovascular events

As reported

RR 0.84, 95% CI 0.74–0.96

Randomised comparison

Reduced cardiovascular events

−23%−35% to −9%

Bigger than 5 in 10 for cardiovascular events

As reported

RR 0.77, 95% CI 0.65–0.91

+3 more in the walkthrough ↓

Seven numbers in the abstract

the abstract, start to end

major cardiovascular events (MACE) (RR = 0.89, 95% CI: 0.82-0.96, P = .002), acute myocardial infarction (AMI) (RR = 0.85, 95% CI: 0.74-0.99, P = .036), all-cause death (RR = 0.84, 95% CI: 0.74-0.96, P = .009), and cardiovascular death (RR = 0.77, 95% CI: 0.65-0.91, P = .002)

not decrease incidence of stroke (RR = 0.86, 95% CI: 0.70-1.04, P = .124).

in placebo-controlled trials (RR = 0.89, 95% CI: 0.83-0.96, P = .004) but not in studies concerning other comparators (RR = 0.58, 95% CI: 0.29-1.16, P = .122).

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
RR 0.890.82–0.96
Cardiovascular events
RR 0.850.74–0.99
Cardiovascular events
RR 0.840.74–0.96
Cardiovascular events
RR 0.770.65–0.91
Cardiovascular events
RR 0.860.70–1.04
Cardiovascular events
RR 0.890.83–0.96
Cardiovascular events
RR 0.580.29–1.16
GLP-1 receptor agonistsCardiovascular events

GLP-1 receptor agonists × cardiovascular eventshelps?mixed

unlikelylikely
0.50not counted
← favours treatmentfavours comparator →
more certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 31725627