Evidence map›Paper›PMID 31729176›Full record

ArticleThe FEBS journal2019

Structural basis of the strong cell-cell junction formed by cadherin-23.

G S Singaraju, A Sagar, A Kumar, J S Samuel, J P Hazra, M K Sannigrahi, R M Yennamalli, Fnu Ashish, S Rakshit

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

G S SingarajuDepartment of Chemical Sciences.
A SagarDepartment of Chemical Sciences.
A KumarDepartment of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Himachal Pradesh, India.
J S SamuelDepartment of Chemical Sciences.
J P HazraDepartment of Chemical Sciences.
M K SannigrahiDepartment of Chemical Sciences.
R M YennamalliDepartment of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Himachal Pradesh, India.
Fnu AshishInstitute of Microbial Technology (CSIR), Chandigarh, India.
S RakshitDepartment of Chemical Sciences.
Indian Institute of Science Education and Research Mohali · INInstitute of Microbial Technology · INJaypee University of Information Technology · IN

Funding

DBT-Wellcome Trust India Alliance IA/I/15/1/501817Wellcome Trust
6 · The paper itself

Abstract

Cadherin-23, a giant atypical cadherin, forms homophilic interactions at the cell-cell junction of epithelial cells and heterophilic interactions with protocadherin-15 at the tip-links of neuroepithelial cells. While the molecular structure of the heterodimer is solved, the homodimer structure is yet to be resolved. The homodimers play an essential role in cell-cell adhesion as the downregulation of cadherin-23 in cancers loosen the intercellular junction resulting in faster-migration of cancer cells and a significant drop in patient survival. In vitro studies have measured a stronger aggregation-propensity of cadherin-23 compared to typical E-cadherin. Here, we deciphered the unique trans-homodimer structure of cadherin-23 in solution, and show that it consists of two electrostatic-based interfaces extended up to two terminal domains. The interface is robust, with a low off-rate of ~8x10

Indexed as

Atypical cadherinsCadherin-23Cell-cell adhesionMolecular Dynamicssingle-molecule Fluorescence resonance energy transfer (smFRET)Single-molecule force spectroscopy (SMFS)Small-angle X-ray scattering (SAXS)

Identifiers

PMID31729176
PMCPMC7317872
OpenAlexW2986034268

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.