Evidence map›Paper›PMID 31731828›Full record

ReviewInternational journal of molecular sciences2019

Roles of Transposable Elements in the Different Layers of Gene Expression Regulation.

Denise Drongitis, Francesco Aniello, Laura Fucci, Aldo Donizetti

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 75 citations in OpenAlex.

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  16. Review
  17. Integration of TE Induces Cancer Specific Alternative Splicing Events.International journal of molecular sciences · 2022
    Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Denise DrongitisInstitute of Genetics and Biophysics "Adriano Buzzati Traverso", Consiglio Nazionale delle Ricerche, 80131 Naples, Italy.
Francesco AnielloDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Laura FucciDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Aldo DonizettiDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0002-4344-0140
University of Naples Federico II · ITInstitute of Genetics and Biophysics · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biology of transposable elements (TEs) is a fascinating and complex field of investigation. TEs represent a substantial fraction of many eukaryotic genomes and can influence many aspects of DNA function that range from the evolution of genetic information to duplication, stability, and gene expression. Their ability to move inside the genome has been largely recognized as a double-edged sword, as both useful and deleterious effects can result. A fundamental role has been played by the evolution of the molecular processes needed to properly control the expression of TEs. Today, we are far removed from the original reductive vision of TEs as "junk DNA", and are more convinced that TEs represent an essential element in the regulation of gene expression. In this review, we summarize some of the more recent findings, mainly in the animal kingdom, concerning the active roles that TEs play at every level of gene expression regulation, including chromatin modification, splicing, and protein translation.

Indexed as

AnimalsDNA Transposable ElementsGene Expression RegulationHumansDNA Transposable Elementsgene expression regulationTEs co-optiontransposable elements

Identifiers

PMID31731828
PMCPMC6888579
OpenAlexW2986911651

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.