Trial reportJournal of endovascular therapy : an official journal of the International Society of Endovascular Specialists2020
Effects of Venous Angioplasty on Cerebral Lesions in Multiple Sclerosis: Expanded Analysis of the Brave Dreams Double-Blind, Sham-Controlled Randomized Trial.
Trial report in Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Internal jugular vein compression: A benign entity or an underappreciated phenomenon?eNeurologicalSci · 2025Article
- May Glymphatic Drainage Improve Life Quality in Progressive Multiple Sclerosis Outpatients?Medical devices (Auckland, N.Z.) · 2024Article
- The reproducibility of interventional radiology randomized controlled trials and external validation of a classification system.Diagnostic and interventional radiology (Ankara, Turkey) · 2023Article
- Results of Numerical Modeling of Blood Flow in the Internal Jugular Vein Exhibiting Different Types of Strictures.Diagnostics (Basel, Switzerland) · 2022Article
- Modelling of the dilated sagittal sinuses found in multiple sclerosis suggests increased wall stiffness may be a contributing factor.Scientific reports · 2022Article
- Potential Surgical Implications of Internal Jugular Stenosis in a Craniocervical Junction Meningioma.Cureus · 2022Article
- Self-Reported Diet and Health Outcomes of Participants of the CCSVI-Tracking Survey Study.Nutrients · 2021Article
- Styloidogenic-cervical spondylotic internal jugular venous compression, a vascular disease related to several clinical neurological manifestations: diagnosis and treatment-a comprehensive literature review.Annals of translational medicine · 2021Review
- Internal Jugular Vein Thrombosis: Etiology, Symptomatology, Diagnosis and Current Treatment.Diagnostics (Basel, Switzerland) · 2021Review
- Vascular Biomarkers: Physics Parameters and Circulating Molecules Can Be Two Faces of the Same Coin.Diagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
- Commented on by
- Erratum issuedCorrigendum.2020
Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate if jugular vein flow restoration in various venographic defects indicative of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis (MS) patients can have positive effects on cerebral lesions identified using magnetic resonance imaging (MRI). MATERIALS AND
methodsThe Brave Dreams trial (
resultsOf the 130 patients enrolled, 125 (96%) completed the 12-month MRI follow-up. Analysis showed that the likelihood of being free of new cerebral lesions at 1 year was significantly higher after venoplasty compared to the sham group (RR 1.42, 95% CI 1.00 to 2.01, p=0.032). Patients with favorable venograms had a significantly higher probability of being free of new cerebral lesions than patients with unfavorable venograms (RR 1.82, 95% CI 1.17 to 2.83, p=0.005) or patients in the sham arm (RR 1.66, 95% CI 1.16 to 2.37, p=0.005).
conclusionExpanded analysis of the Brave Dreams data that included secondary/progressive MS patients in addition to the relapsing/remitting patients analyzed previously showed that venoplasty decreases new cerebral lesions at 1 year. Secondary analysis confirmed the efficacy of the Giaquinta grading system in selecting patients appropriate for venoplasty who were more likely to be free from accumulation of new cerebral lesions at MRI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.