ReviewFrontiers in genetics2019
Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement Strategies.
Review in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Advances in mosquito gut microbiota: Mechanisms of regulating pathogen transmission and applications in vector control.Virulence · 2026Review
- Advances in CRISPR gene drives for mosquito population control.Current opinion in microbiology · 2026Review
- Cryopreservation of Anopheles gambiae Larvae.Advanced biology · 2026Article
- A model-informed target product profile for population modification gene drives for malaria control.PLOS global public health · 2025Article
- MGSurvE: A framework to optimize trap placement for genetic surveillance of mosquito populations.PLoS computational biology · 2024Article
- Article
- Advances and challenges in synthetic biology for mosquito control.Trends in parasitology · 2024Review
- Article
- Manipulating the Destiny of Wild Populations Using CRISPR.Annual review of genetics · 2023Review
- Targeting Sex Determination to Suppress Mosquito Populations.bioRxiv : the preprint server for biology · 2023Article
- Targeting Sex Determination to Suppress Mosquito Populations.Research square · 2023Article
- Maxizyme-mediated suppression of chikungunya virus replication and transmission in transgenicFrontiers in microbiology · 2023Article
- Combating mosquito-borne diseases using genetic control technologies.Nature communications · 2021Review
- Article
- Control of malaria-transmitting mosquitoes using gene drives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- A population genomic unveiling of a new cryptic mosquito taxon within the malaria-transmitting Anopheles gambiae complex.Molecular ecology · 2021Article
- Next-generation tools to control biting midge populations and reduce pathogen transmission.Parasites & vectors · 2021Review
- Monitoring Needs for Gene Drive Mosquito Projects: Lessons From Vector Control Field Trials and Invasive Species.Frontiers in genetics · 2021Article
- Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi.Nature communications · 2020Article
- Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives.EFSA journal. European Food Safety Authority · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While efforts to control malaria with available tools have stagnated, and arbovirus outbreaks persist around the globe, the advent of clustered regularly interspaced short palindromic repeat (CRISPR)-based gene editing has provided exciting new opportunities for genetics-based strategies to control these diseases. In one such strategy, called "population replacement", mosquitoes, and other disease vectors are engineered with effector genes that render them unable to transmit pathogens. These effector genes can be linked to "gene drive" systems that can bias inheritance in their favor, providing novel opportunities to replace disease-susceptible vector populations with disease-refractory ones over the course of several generations. While promising for the control of vector-borne diseases on a wide scale, this sets up an evolutionary tug-of-war between the introduced effector genes and the pathogen. Here, we review the disease-refractory genes designed to date to target
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.