Evidence map›Paper›PMID 31737860›Full record

ArticleCurrent developments in nutrition2019

Impact of Red Beetroot Juice on Vascular Endothelial Function and Cardiometabolic Responses to a High-Fat Meal in Middle-Aged/Older Adults with Overweight and Obesity: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.

Nicole S Litwin, Hannah J Van Ark, Shannon C Hartley, Kiri A Michell, Allegra R Vazquez, Emily K Fischer, Christopher L Melby, Tiffany L Weir, Yuren Wei, Sangeeta Rao and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current developments in nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02949115 (Acute and Chronic Effects of Red Beetroot Juice on High-Fat Meal-Induced Endothelial Dysfunction and Cardiometabolic Disturbances), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02949115 phase2unknown statusnot on this map

Acute and Chronic Effects of Red Beetroot Juice on High-Fat Meal-Induced Endothelial Dysfunction and Cardiometabolic Disturbances

TypeinterventionalSponsorColorado State UniversityRan2016 to 2019Enrolled15ConditionsOverweight, Obesity, Aging, MenopauseArms70 mL red beetroot juice, 70 mL red beetroot juice without nitrate, 70 mL placebo drink plus potassium nitrate, 70 mL placebo drink
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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  7. Beneficial microbes · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Nicole S LitwinDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Hannah J Van ArkDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Shannon C HartleyDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Kiri A MichellDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Allegra R VazquezDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Emily K FischerDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Christopher L MelbyDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Tiffany L WeirDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Yuren WeiDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Sangeeta RaoDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
Kerry L HildrethDivision of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Douglas R SealsDepartment of Integrative Physiology, University of Colorado-Boulder, Boulder, CO, USA.
Michael J PagliassottiDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Sarah A JohnsonDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Colorado State University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Boulder · US

Funding

NCATS NIH HHS UL1 TR001082
6 · The paper itself

Abstract

backgroundHigh-fat meal (HFM) consumption may induce transient postprandial atherogenic responses, including impairment of vascular endothelial function, in individuals with overweight/obesity. Red beetroot juice (RBJ) may modulate endothelial function and other measures of cardiometabolic health.

objectiveThis study investigated the impact of acute and chronic RBJ consumption, including nitrate-dependent and -independent effects, on postprandial endothelial function and other cardiometabolic responses to a HFM.

methodsFifteen men and postmenopausal women with overweight/obesity were enrolled in this randomized, double-blind, placebo-controlled, 4-period, crossover clinical trial. Following an overnight fast, participants underwent baseline assessment of endothelial function (reactive hyperemia index; RHI) and hemodynamics, and biological sample collection. In random order, participants consumed 70 mL (acute visit) of:

resultsHFM consumption did not induce significant impairment of postprandial RHI. No significant differences in RHI were detected across treatment groups following acute or chronic exposure, despite increases in circulating nitrate/nitrite (NOx) concentrations in the RBJ and PBO + NIT groups compared with PBO and NF-RBJ (

conclusionsHFM consumption did not impair postprandial endothelial function in this population, and RBJ exposure did not alter postprandial endothelial function or other outcomes despite increasing NOx concentrations. This trial is registered at clinicaltrials.gov as NCT02949115.

Indexed as

betalainscardiovascular diseasedietary nitrateinflammationnitric oxideoxidative stresspostprandial dysmetabolismvascular functionvasodilation

Identifiers

PMID31737860
PMCPMC6848269
OpenAlexW2981103735

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.