ReviewChemical reviews2019
Inorganic Polyphosphates As Storage for and Generator of Metabolic Energy in the Extracellular Matrix.
Review in Chemical reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 182 citations in OpenAlex.
- Inorganic polyphosphate chelates CaBiochemistry and biophysics reports · 2026Article
- Polyphosphate in Bone Tissue Engineering: From Molecular Mechanisms to Material Design.Journal of functional biomaterials · 2026Review
- Inorganic Polyphosphate in Hematolymphoid Malignancies: Biological Rationale and Emerging Research Gaps.Biomolecules · 2026Review
- A Novel Polyphosphate-Degrading Enzyme Confers Growth on Exogenous Polyphosphate in the Archaeon Haloferax volcanii.Environmental microbiology · 2026Article
- Polyphosphate Attenuates Oxidative Stress to Support Temperature Adaptability in Hot Spring Cyanobacteria.Plants (Basel, Switzerland) · 2026Article
- A GMP-compliant formulation of regeneratively active polyphosphate for wound healing and skin regeneration.Biomaterials science · 2026Article
- ATP regeneration-driven biocatalytic production of 1,12-dodecanediol with improved cofactor supply.Bioresources and bioprocessing · 2026Article
- hBM-MSC-Laden 3D Bioprinted Gelatin-Alginate Hydrogels: Physicochemical Characterisation and Osteogenic Lineage Commitment.Gels (Basel, Switzerland) · 2026Article
- Long-chain polyphosphates induce glomerular microthrombi and exacerbate LPS-induced acute kidney injury in mouse.Disease models & mechanisms · 2026Article
- Phosphate availability modulates elemental homeostasis in rainbow trout hepatocytes: compositional ionomics illuminates system-wide adjustments.Metallomics : integrated biometal science · 2026Article
- DNA Damage and Skin Injuries Caused by Ionizing Radiation and Strategies for Wound Healing.Progress in molecular and subcellular biology · 2026Review
- Chronic Wound Healing: Breakthrough Strategies Based on Inorganic Polyphosphate.Progress in molecular and subcellular biology · 2026Review
- Mucosal Wound Repair: Reinforcement of Respiratory Mucus Barrier Function by Inorganic Polyphosphate.Progress in molecular and subcellular biology · 2026Review
- Inorganic Polyphosphate and Human Diseases.Progress in molecular and subcellular biology · 2026Review
- Inorganic Polyphosphate and Alkaline Phosphatase/Adenylate Kinase: Key Components of the Physiological ATP-Dependent Wound Repair and Mode of Action.Progress in molecular and subcellular biology · 2026Review
- Energy Metabolic Regulatory Materials Promote Wound Healing in Senescent Environment.Progress in molecular and subcellular biology · 2026Review
- Coming to Terms: The Mechanisms of Overplus and Luxury Phosphorus Uptake for Polyphosphate Storage in Microalgae and Yeast.Biotechnology and bioengineering · 2025Review
- Bioenergetic-active hydrogel drives extracellular matrix synthesis for cartilage repair.Bioactive materials · 2025Article
- Review
- Polyphosphate Polymerase-A Key Enzyme for the Phosphorus Economy of the Microalgal Cell and the Sustainable Usage of This Nutrient.Plants (Basel, Switzerland) · 2025Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inorganic polyphosphates (polyP) consist of linear chains of orthophosphate residues, linked by high-energy phosphoanhydride bonds. They are evolutionarily old biopolymers that are present from bacteria to man. No other molecule concentrates as much (bio)chemically usable energy as polyP. However, the function and metabolism of this long-neglected polymer are scarcely known, especially in higher eukaryotes. In recent years, interest in polyP experienced a renaissance, beginning with the discovery of polyP as phosphate source in bone mineralization. Later, two discoveries placed polyP into the focus of regenerative medicine applications. First, polyP shows morphogenetic activity, i.e., induces cell differentiation via gene induction, and, second, acts as an energy storage and donor in the extracellular space. Studies on acidocalcisomes and mitochondria provided first insights into the enzymatic basis of eukaryotic polyP formation. In addition, a concerted action of alkaline phosphatase and adenylate kinase proved crucial for ADP/ATP generation from polyP. PolyP added extracellularly to mammalian cells resulted in a 3-fold increase of ATP. The importance and mechanism of this phosphotransfer reaction for energy-consuming processes in the extracellular matrix are discussed. This review aims to give a critical overview about the formation and function of this unique polymer that is capable of storing (bio)chemically useful energy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.