Evidence map›Paper›PMID 31742469›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and

Lingling Yang, Feng Chen, Cheng Gao, Jiabao Chen, Junyan Li, Siyan Liu, Yuanyuan Zhang, Zhouyu Wang, Shan Qian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Lingling YangDepartment of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu, China.
Feng ChenDepartment of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu, China.
Cheng GaoDepartment of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu, China.
Jiabao ChenDepartment of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu, China.
Junyan LiDepartment of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu, China.
Siyan LiuDepartment of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu, China.
Yuanyuan ZhangDepartment of Chemistry, College of Science, Xihua University, Chengdu, China.
Zhouyu WangDepartment of Chemistry, College of Science, Xihua University, Chengdu, China.
Shan QianDepartment of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu, China.
Xihua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overexpression of protein tyrosine phosphatase 1B (PTP1B) induces insulin resistance in various basic and clinical research. In our previous work, a synthetic oleanolic acid (OA) derivative

Indexed as

Drug DesignAnimalsBlood GlucoseDiabetes Mellitus, Type 2Disease Models, AnimalDose-Response Relationship, DrugEnzyme InhibitorsHep G2 CellsHumansHypoglycemic AgentsInsulin ResistanceMaleMiceMice, Inbred StrainsMolecular StructureProtein Tyrosine Phosphatase, Non-Receptor Type 1Blood GlucoseEnzyme InhibitorsHypoglycemic AgentsProtein Tyrosine Phosphatase, Non-Receptor Type 1PTPN1 protein, humanTerpenesantihyperglycaemic effectinsulin-resistantoleanolic acidProtein tyrosine phosphatase 1Btype 2 diabetes

Identifiers

PMID31742469
PMCPMC6882489
OpenAlexW2990109268

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.