Evidence map›Paper›PMID 31744203›Full record

ArticlePharmaceuticals (Basel, Switzerland)2019

Biological Evaluation of Arylsemicarbazone Derivatives as Potential Anticancer Agents.

Anne Cecília Nascimento da Cruz, Dalci José Brondani, Temístocles I Talo de Santana, Lucas Oliveira da Silva, Elizabeth Fernanda da Oliveira Borba, Antônio Rodolfo de Faria, Julianna Ferreira Cavalcanti de Albuquerque, Sylvie Piessard, Rafael Matos Ximenes, Blandine Baratte and 8 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anne Cecília Nascimento da CruzDepartamento de Antibióticos, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, 50740-520, Brazil.
Dalci José BrondaniDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, 50740-520, Brazil.
Temístocles I Talo de SantanaDepartamento de Antibióticos, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, 50740-520, Brazil.
Lucas Oliveira da SilvaDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, 50740-520, Brazil.
Elizabeth Fernanda da Oliveira BorbaDepartamento de Antibióticos, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, 50740-520, Brazil.
Antônio Rodolfo de FariaDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, 50740-520, Brazil.
Julianna Ferreira Cavalcanti de AlbuquerqueDepartamento de Antibióticos, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, 50740-520, Brazil.
Sylvie PiessardUniversité de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, Nantes, F-44000, France.
Rafael Matos XimenesDepartamento de Antibióticos, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, 50740-520, Brazil.
Blandine BaratteSorbonne Université, CNRS, USR3151, « Protein phosphorylation and human diseases » Unit, Station Biologique, Roscoff, F-29688, France.
Stéphane BachSorbonne Université, CNRS, USR3151, « Protein phosphorylation and human diseases » Unit, Station Biologique, Roscoff, F-29688, France.
Sandrine RuchaudSorbonne Université, CNRS, USR3151, « Protein phosphorylation and human diseases » Unit, Station Biologique, Roscoff, F-29688, France.
Francisco Jaime Bezerra Mendonça JuniorLaboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraiba, João Pessoa, PB, 58071-160, Brazil.
Marc-Antoine BazinUniversité de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, Nantes, F-44000, France.
Marcelo Montenegro RabelloDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, 50740-520, Brazil.
Marcelo Zaldini HernandesDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, 50740-520, Brazil.
Pascal MarchandUniversité de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, Nantes, F-44000, France.
Teresinha Gonçalves da SilvaDepartamento de Antibióticos, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, 50740-520, Brazil.

Funding

Capes/Cofecub Program Me 865-15
6 · The paper itself

Abstract

Fourteen arylsemicarbazone derivatives were synthesized and evaluated in order to find agents with potential anticancer activity. Cytotoxic screening was performed against K562, HL-60, MOLT-4, HEp-2, NCI-H292, HT-29 and MCF-7 tumor cell lines. Compounds

Indexed as

anticancer activityapoptosiscell cyclecytotoxicitykinase inhibitionsemicarbazones

Identifiers

PMID31744203
PMCPMC6958387

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.