ReviewAfrican journal of disability2019
The health benefits of exercise therapy for patients with Down syndrome: A systematic review.
Review in African journal of disability, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Impact of tele-exercise on quality of life, physical fitness, functional capacity and strength in different adult populations: a systematic review of clinical trials.Frontiers in sports and active living · 2025Pooled it
- Effects of therapeutic exercise on the motor function of adults with Down syndrome: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Therapeutic exercise to improve motor function among children with Down Syndrome aged 0 to 3 years: a systematic literature review and meta‑analysis.Scientific reports · 2022Pooled it
- Effectiveness of Swimming Program in Adolescents with Down Syndrome.International journal of environmental research and public health · 2021Trial
- Effects of Physical Activity on Motor Development, Balance, and Psychosocial Well-Being in Children and Adolescents with Down Syndrome: A Systematic Review.Journal of clinical medicine · 2026Review
- Examination of metabolic syndrome in Down syndrome and association with dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Lifestyle Intervention Improves Metabolic Dysfunction-Associated Steatotic Liver Disease in Children with Down Syndrome.Nutrients · 2025Article
- A Tele-Coaching Pilot Study: An Innovative Approach to Enhance Motor Skills in Adolescents With Down Syndrome.Journal of applied research in intellectual disabilities : JARID · 2025Article
- Strength versus aerobic program: effects on body composition and health-related physical fitness levels of youths with Down syndrome.International journal of developmental disabilities · 2024Article
- Effects of exercise, physical activity, and sports on physical fitness in adults with Down syndrome: A systematic review.AIMS public health · 2024Review
- Long-Term Non-Congenital Cardiac and Renal Complications in Down Syndrome: A Study of 32,936 Patients.Children (Basel, Switzerland) · 2023Article
- Benefits of Treadmill Training for Patients with Down Syndrome: A Systematic Review.Brain sciences · 2023Review
- Development of a Physical Therapy-Based Exercise Program for Adults with Down Syndrome.International journal of environmental research and public health · 2023Review
- Aquatic exercise for people with intellectual disabilities: findings from a systematic review.International journal of developmental disabilities · 2023Review
- Physical activity, sedentary behaviour and screen time among youths with Down syndrome during the COVID-19 pandemic.Journal of intellectual disability research : JIDR · 2022Article
- Accelerometer-based estimation of oxygen uptake in adults with Down syndrome: vector magnitude vs. vertical axis.Journal of intellectual disability research : JIDR · 2022Article
- Effects of early physical therapy on motor development in children with Down syndrome.Northern clinics of Istanbul · 2022Article
- Prospective Associations of Physical Activity and Health-Related Physical Fitness in Adolescents with Down Syndrome: The UP&DOWN Longitudinal Study.International journal of environmental research and public health · 2021Article
- Metabolic Diseases and Down Syndrome: How Are They Linked Together?Biomedicines · 2021Review
- Intellectual Disabilities Behavior Under the Lens of Embodied Cognition Approaches.Frontiers in psychology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany patients with Down syndrome (PWDS) have poor cardiometabolic risk profiles, aerobic capacities and weak hypotonic muscles, primarily because of physical inactivity and poor diet.
objectivesThis study discusses the benefits of exercise therapy on body composition, aerobic capacity, muscle strength, proprioception and cardiometabolic profiles of PWDS.
methodsA literature review using the Crossref metadatabase, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), focusing on the period 2007-2018, was undertaken. Each record was judged adopting the modified Downs and Black Appraisal Scale. The literature investigation identified 15 701 records. Records were excluded if they were published before 2007, pertained to the impact of exercise on intellectual disabilities beyond Down syndrome or the impact of medical, pharmaceutical, nutrition and psychological interventions among PWDS and were published in languages besides English. Nineteen articles were synthesised into this commentary.
resultsPWDS have a heightened cardiometabolic risk profile and high oxidative stress associated with elevated insulin resistance, poor insulin sensitivity, atherosclerosis and hypertension. PWDS have low aerobic capacity (VO
conclusionExercise therapy compliance seems to have a positive impact on the cardiometabolic risk profile, muscle strength and aerobic work capacity of PWDS. Nonetheless, additional vigorous experimental investigations are necessary to better understand the effect of exercise therapy on the aerobic, strength, proprioception and cardiometabolic risk profile of PWDS.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.