Evidence map›Paper›PMID 31748847›Full record

ArticleInflammation2020

LINC01140 Alleviates the Oxidized Low-Density Lipoprotein-Induced Inflammatory Response in Macrophages via Suppressing miR-23b.

Liping He, Xingsheng Zhao, Leping He

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Liping HeDepartment of Cardiology, People's Hospital of Inner Mongolia Autonomous region, No. 20 of Zhaowuda Road, Hohhot city, 010020, Inner Mongolia, China.
Xingsheng ZhaoDepartment of Cardiology, People's Hospital of Inner Mongolia Autonomous region, No. 20 of Zhaowuda Road, Hohhot city, 010020, Inner Mongolia, China. xiashe2992559@163.com.
Leping HeThe Center of Computer Information, People's Hospital of Inner Mongolia Autonomous region, Hohhot, 010020, Inner Mongolia, China.
Inner Mongolia People's Hospital · CN

Funding

Scientific and Technological Project of Inner Mongolia Autonomous Region 201602098
6 · The paper itself

Abstract

Our previous study has demonstrated that miR-23b enhances oxidized low-density lipoprotein (oxLDL)-induced inflammatory response of macrophages through the A20/NF-κB signaling pathway, thus contributing to atherosclerosis. This study aims to further investigate the upstream regulators of miR-23b in mediating oxLDL-induced inflammatory response. Human monocyte cell line THP1 was induced to differentiate into macrophages followed by the oxLDL stimulation of inflammatory response. The expression of miR-23b, LINC01140, and p53 mRNA was detected by quantitative PCR. The combination of miR-23b and LINC01140 was confirmed by luciferase reporter assay and RNA immunoprecipitation. The binding of p53 and LINC01140 promoter was determined by luciferase reporter assay. The level of inflammatory cytokines, including MCP-1, TNF-α, and IL-1β, was assessed by enzyme-linked immunosorbent assay. LINC01140 was downregulated, while p53 and miR-23b were upregulated in oxLDL-induced inflammatory response of macrophages. Overexpression of LINC01140 reduced NF-κB activity by reducing miR-23b and increasing A20. The transcription of LINC01140 was inhibited by binding of p53 and the LINC01140 promoter region. Knockdown of p53 significantly reduced NF-κB activity and level of inflammatory cytokines by promoting LINC01140 expression. Our findings demonstrated that LINC01140 acts as an anti-inflammatory factor through negatively regulating miR-23/A20 axis. In addition, p53 is identified as a transcriptional repressor of LINC01140.

Indexed as

CytokinesGene Expression RegulationHumansInflammationLipoproteins, LDLMacrophage ActivationMacrophagesMicroRNAsRNA, Long NoncodingSignal TransductionTHP-1 CellsTumor Suppressor Protein p53CytokinesLipoproteins, LDLMicroRNAsMIRN23b microRNA, humanoxidized low density lipoproteinRNA, Long NoncodingTP53 protein, humanTumor Suppressor Protein p53A20long non-coding RNAmacrophageNF-κb activityp53

Identifiers

PMID31748847
OpenAlexW2991538937

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.