Evidence map›Paper›PMID 31748963›Full record

SynthesisCurrent atherosclerosis reports2019

Low-Density Lipoprotein Cholesterol and Risk of Hemorrhagic Stroke: a Systematic Review and Dose-Response Meta-analysis of Prospective Studies.

Chaoran Ma, Muzi Na, Samantha Neumann, Xiang Gao

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current atherosclerosis reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Article
  8. Review
  9. Observational
  10. Article
  11. How Low Is Too Low? A Retrospective Analysis of Very Low LDL-C Levels in Veterans.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2022
    Article
  12. Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chaoran MaDepartment of Nutritional Sciences, Pennsylvania State University, 110 Chandlee Lab, University Park, PA, 16802, USA.
Muzi NaDepartment of Nutritional Sciences, Pennsylvania State University, 110 Chandlee Lab, University Park, PA, 16802, USA.
Samantha NeumannEberly College of Science, Pennsylvania State University, University Park, PA, 16802, USA.
Xiang GaoDepartment of Nutritional Sciences, Pennsylvania State University, 110 Chandlee Lab, University Park, PA, 16802, USA. xxg14@psu.edu.
Pennsylvania State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewTo systematically examine the association between low-density lipoprotein cholesterol (LDL-C) and risk of hemorrhagic stroke. RECENT

findingsA previous meta-analysis of prospective studies published in 2013 showed that higher concentrations of LDL-C were associated with lower risk of hemorrhagic stroke. Recently, seven large cohort studies were published examining LDL-C and risk of hemorrhagic stroke in different populations. Twelve prospective studies with 476,173 participants and 7587 hemorrhagic stroke cases were included in the current meta-analysis. The results showed that a 10 mg/dL increase in LDL-C was associated with 3% lower risk of hemorrhagic stroke (pooled relative risk [RR] 0.97, 95% confidence interval [CI] 0.95-0.98). The association appeared to be more pronounced in Asians (pooled RR 0.95, 95% CI 0.92-0.98), relative to Caucasians (pooled RR 0.98, 95% CI 0.97-1.00), with a p heterogeneity of 0.05 between two ethnic groups. Further genetic studies and clinical trials with a stricter safety monitoring strategy are warranted to understand the underlying pathogenesis and determine the treatment target of LDL-C range with the lowest risk of hemorrhagic stroke in different population groups.

Indexed as

AgedBiomarkersCholesterol, LDLFemaleHumansIntracranial HemorrhagesMaleMiddle AgedProspective StudiesRisk FactorsStrokeBiomarkersCholesterol, LDLDose-responseHemorrhagic strokeLDL-CMeta-analysisProspective studies

Identifiers

PMID31748963
OpenAlexW2991053991

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.