Evidence map›Paper›PMID 31754030›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation.

Troy A McDiarmid, Manuel Belmadani, Joseph Liang, Fabian Meili, Eleanor A Mathews, Gregory P Mullen, Ardalan Hendi, Wan-Rong Wong, James B Rand, Kota Mizumoto and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Article
  2. Loss ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Infant sensory gating and a developmental cascade to autistic traits and anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Autism risk variants inmicroPublication biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Antioxidants, Hormetic Nutrition, and Autism.Current neuropharmacology · 2024
    Review
  19. Article
  20. Conserved autism-associated genes tune social feeding behavior inbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Troy A McDiarmidDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Manuel BelmadaniDepartment of Psychiatry, University of British Columbia, Vancouver, BC V6T 2A1, Canada.
Joseph LiangDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Fabian MeiliDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Eleanor A MathewsGenetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Gregory P MullenBiology Program, Oklahoma City University, Oklahoma City, OK 73106.
Ardalan HendiDepartment of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Wan-Rong WongDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
James B RandGenetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Kota MizumotoDepartment of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Kurt HaasDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Paul PavlidisDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Catharine H RankinDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 2B5, Canada; crankin@psych.ubc.ca.ORCID 0000-0002-1781-0654

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
CIHR MOP 130287NIH HHS P40 OD010440
6 · The paper itself

Abstract

A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and growing number of candidate risk genes and gene variants of unknown functional significance. Here, we used

Indexed as

AnimalsAnimals, Genetically ModifiedAutism Spectrum DisorderBehavior, AnimalBehavior Observation TechniquesCaenorhabditis elegansCell Adhesion Molecules, NeuronalDisease Models, AnimalDNA-Binding ProteinsEpistasis, GeneticHabituation, PsychophysiologicHumansImmunoglobulinsLocomotionMembrane ProteinsMutation, MissenseCell Adhesion Molecules, NeuronalCHD8 protein, humanDNA-Binding ProteinsImmunoglobulinsKIRREL2 protein, humanMembrane Proteinsneuroligin 1Transcription Factorsautism spectrum disorderCaenorhabditis eleganshabituation learningneurodevelopmental disordersvariants of uncertain significance

Identifiers

PMID31754030
PMCPMC6968627

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.